FRS2

Fibroblast growth factor receptor substrate 2 is a protein that in humans is encoded by the FRS2 gene.^[4][5][6][7]

FRS2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1XR0, 2MFQ
Identifiers
Aliases	FRS2, FRS2A, FRS2alpha, SNT, SNT-1, SNT1, FRS1A, fibroblast growth factor receptor substrate 2
External IDs	OMIM: 607743; MGI: 1100860; HomoloGene: 4846; GeneCards: FRS2; OMA:FRS2 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q15 Start 69,470,349 bp[1] End 69,579,793 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon endothelial cell ventricular zone testicle epithelium of colon gonad ganglionic eminence islet of Langerhans stromal cell of endometrium C1 segment n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transmembrane receptor protein tyrosine kinase adaptor activity fibroblast growth factor receptor binding neurotrophin TRKA receptor binding protein binding phosphatase activator activity 1-phosphatidylinositol-3-kinase activity phosphatidylinositol-4,5-bisphosphate 3-kinase activity Cellular component cytoplasm endosome membrane plasma membrane integral component of plasma membrane endomembrane system cell-cell junction cytosol Biological process regulation of apoptotic process G protein-coupled receptor signaling pathway ventricular septum development organ induction transmembrane receptor protein tyrosine kinase signaling pathway gastrulation with mouth forming second MAPK cascade lens placode formation involved in camera-type eye formation fibroblast growth factor receptor signaling pathway transmembrane receptor protein tyrosine phosphatase signaling pathway lens development in camera-type eye prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis regulation of ERK1 and ERK2 cascade neuroblast proliferation forebrain development regulation of epithelial cell proliferation anterior/posterior axis specification, embryo lens fiber cell development phosphatidylinositol phosphate biosynthetic process phosphatidylinositol-3-phosphate biosynthetic process axon guidance negative regulation of cardiac muscle cell differentiation positive regulation of protein kinase B signaling neurotrophin TRK receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10818 327826 Ensembl ENSG00000166225 ENSMUSG00000020170 UniProt Q8WU20 Q8C180 RefSeq (mRNA) NM_006654 NM_001042555 NM_001278351 NM_001278353 NM_001278354 NM_001278355 NM_001278356 NM_001278357 NM_177798 RefSeq (protein) NP_001036020 NP_001265280 NP_001265282 NP_001265283 NP_001265284 NP_001265285 NP_001265286 NP_006645 NP_808466 NP_001395211 NP_001395212 NP_001395213 NP_001395214 NP_001395215 NP_001395216 NP_001395217 NP_001395218 NP_001395219 NP_001395220 NP_001395221 NP_001395222 NP_001395223 NP_001395224 NP_001395225 NP_001395226 NP_001395237 NP_001395238 NP_001395239 NP_001395240 NP_001395241 NP_001395242 NP_001395243 Location (UCSC) Chr 12: 69.47 – 69.58 Mb n/a PubMed search [2] [3]
Wikidata
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FRS2 is an 80 kDa membrane-anchored signal transducing adaptor protein (STAP) that links specific activated Receptor Tyrosine Kinases (RTKs) to multiple downstream signaling pathways, most notably the MAPK/ERK, PI3K/AKT/mTOR and PLCγ pathways.^[8] It is overexpressed and amplified in several cancer types, including prostate cancer.^[9][10]

Interactions

FRS2 has been shown to interact with:

• CBL^[11]
• FGFR1^{[6][12][13][14]}
• GRB2^{[11][15][16][17]}
• PRKCI^[18]
• PTPN11^[19][20][21]
• SOS1^[11][17][22]
• TrkA^[16]
• ALK^[23]