RGS19

Regulator of G-protein signaling 19 is a protein that in humans is encoded by the RGS19 gene.^[5][6]

RGS19
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1CMZ
Identifiers
Aliases	RGS19, GAIP, RGSGAIP, regulator of G-protein signaling 19, regulator of G protein signaling 19
External IDs	OMIM: 605071; MGI: 1915153; HomoloGene: 23320; GeneCards: RGS19; OMA:RGS19 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.33 Start 64,073,181 bp[1] End 64,079,988 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 H4|2 103.72 cM Start 181,330,212 bp[2] End 181,335,770 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte blood monocyte spleen bone marrow cells parotid gland trabecular bone lymph node amniotic fluid appendix Top expressed in granulocyte mesenteric lymph nodes external carotid artery spleen blood thymus internal carotid artery yolk sac condyle tibiofemoral joint More reference expression data BioGPS More reference expression data
Gene ontology Molecular function GTPase activator activity protein binding G-protein alpha-subunit binding GTPase activity Cellular component cytoplasm Golgi apparatus membrane brush border heterotrimeric G-protein complex membrane raft clathrin-coated vesicle cytoplasmic vesicle plasma membrane Biological process G protein-coupled receptor signaling pathway small GTPase mediated signal transduction autophagy negative regulation of signal transduction positive regulation of GTPase activity response to ethanol Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10287 56470 Ensembl ENSG00000171700 ENSMUSG00000002458 UniProt P49795 Q9CX84 RefSeq (mRNA) NM_001039467 NM_005873 NM_001291205 NM_001291206 NM_001291207 NM_001291208 NM_001291209 NM_001291210 NM_026446 RefSeq (protein) NP_001034556 NP_005864 NP_001278134 NP_001278135 NP_001278136 NP_001278137 NP_001278138 NP_001278139 NP_080722 Location (UCSC) Chr 20: 64.07 – 64.08 Mb Chr 2: 181.33 – 181.34 Mb PubMed search [3] [4]
Wikidata
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G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators of G-protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine triphosphatase-activating protein that functions to down-regulate Galpha i/Galpha q-linked signaling.^[6][7]

Interactions

RGS19 has been shown to interact with GNAO1,^[8][9] GIPC1,^[10] OSTM1,^[11] GNAI1,^[8][9] GNAI3^[5][8][9] and GNAZ.^[8][12]