GOSR1

Golgi SNAP receptor complex member 1 is a protein that in humans is encoded by the GOSR1 gene.^[5][6][7][8]

GOSR1
Identifiers
Aliases	GOSR1, GOLIM2, GOS-28, GOS28, GOS28/P28, GS28, P28, golgi SNAP receptor complex member 1
External IDs	OMIM: 604026; MGI: 1858260; HomoloGene: 37977; GeneCards: GOSR1; OMA:GOSR1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q11.2 Start 30,477,362 bp[1] End 30,527,592 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B5 Start 76,617,428 bp[2] End 76,654,405 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell nipple tibia visceral pleura caput epididymis Achilles tendon pancreatic ductal cell parietal pleura corpus epididymis tail of epididymis Top expressed in lumbar subsegment of spinal cord stroma of bone marrow left lung lobe granulocyte jejunum epithelium of stomach parotid gland aortic valve seminal vesicula subcutaneous adipose tissue More reference expression data BioGPS n/a
Gene ontology Molecular function SNAP receptor activity SNARE binding Cellular component integral component of membrane Golgi membrane cis-Golgi network Golgi apparatus SNARE complex membrane Golgi medial cisterna cytosol transport vesicle Biological process protein transport endoplasmic reticulum to Golgi vesicle-mediated transport vesicle fusion intra-Golgi vesicle-mediated transport retrograde transport, endosome to Golgi regulation of vesicle targeting, to, from or within Golgi vesicle-mediated transport transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9527 53334 Ensembl ENSG00000108587 ENSMUSG00000010392 UniProt O95249 O88630 RefSeq (mRNA) NM_001007024 NM_001007025 NM_004871 NM_016810 NM_001356321 RefSeq (protein) NP_001007025 NP_001007026 NP_004862 NP_058090 NP_001343250 Location (UCSC) Chr 17: 30.48 – 30.53 Mb Chr 11: 76.62 – 76.65 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a trafficking membrane protein which transports proteins among the endoplasmic reticulum and the Golgi apparatus and between Golgi compartments. This protein is considered an essential component of the Golgi SNAP receptor (SNARE) complex. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.^[8]

Interactions

GOSR1 has been shown to interact with USO1,^[9] BET1L^[9][10] and STX5.^{[9][11][12][13]}