USO1

General vesicular transport factor p115 is a protein that in humans is encoded by the USO1 gene.^{[5][6][7][8][9][10]}

USO1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2W3C
Identifiers
Aliases	USO1, P115, TAP, VDP, USO1 vesicle transport factor
External IDs	OMIM: 603344; MGI: 1929095; HomoloGene: 2754; GeneCards: USO1; OMA:USO1 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q21.1 Start 75,724,577 bp[1] End 75,814,286 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 E2 Start 92,285,797 bp[2] End 92,350,657 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in glutes Skeletal muscle tissue of biceps brachii deltoid muscle parotid gland triceps brachii muscle tibia thoracic diaphragm Skeletal muscle tissue of rectus abdominis tibialis anterior muscle corpus epididymis Top expressed in lacrimal gland seminal vesicula calvaria salivary gland parotid gland zygote islet of Langerhans temporal muscle body of femur submandibular gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding RNA binding cadherin binding Cellular component cytoplasm cytosol Golgi apparatus membrane Golgi membrane transport vesicle endoplasmic reticulum perinuclear region of cytoplasm ER to Golgi transport vesicle membrane Golgi stack fibrillar center Biological process vesicle fusion with Golgi apparatus membrane fusion transcytosis endoplasmic reticulum to Golgi vesicle-mediated transport COPII vesicle coating Golgi vesicle docking protein transport intracellular protein transport vesicle-mediated transport Golgi organization transport small GTPase mediated signal transduction secretory granule localization regulation of cellular response to insulin stimulus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8615 56041 Ensembl ENSG00000138768 ENSMUSG00000029407 UniProt O60763 Q9Z1Z0 RefSeq (mRNA) NM_001290049 NM_003715 NM_019490 RefSeq (protein) NP_001276978 NP_003706 NP_062363 Location (UCSC) Chr 4: 75.72 – 75.81 Mb Chr 5: 92.29 – 92.35 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a peripheral membrane protein which recycles between the cytosol and the Golgi apparatus during interphase. It is regulated by phosphorylation: dephosphorylated protein associates with the Golgi membrane and dissociates from the membrane upon phosphorylation. Ras-associated protein 1 recruits this protein to coat protein complex II (COPII) vesicles during budding from the endoplasmic reticulum (ER), where it interacts with a set of COPII vesicle-associated SNAREs to form a cis-SNARE complex that promotes targeting to the Golgi apparatus. Transport from the ER to the cis/medial Golgi compartments requires the action of this gene product, GOLGA2, and giantin in a sequential manner.^[10]

Interactions

USO1 has been shown to interact with:

• GOSR1,^[11]
• GOSR2,^[11][12]
• SCFD1,^[11][12] and
• STX5.^[11][12]