HTATSF1

HIV Tat-specific factor 1 is a protein that in humans is encoded by the HTATSF1 gene.^[5][6]

HTATSF1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DIT
Identifiers
Aliases	HTATSF1, TAT-SF1, TATSF1, dJ196E23.2, HIV-1 Tat specific factor 1
External IDs	OMIM: 300346; MGI: 1919709; HomoloGene: 40950; GeneCards: HTATSF1; OMA:HTATSF1 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq26.3 Start 136,497,079 bp[1] End 136,512,346 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X A6 Start 56,098,943 bp[2] End 56,112,543 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve Skeletal muscle tissue of rectus abdominis pituitary gland germinal epithelium internal globus pallidus epithelium of nasopharynx ganglionic eminence tendon of biceps brachii vastus lateralis muscle anterior pituitary Top expressed in pituitary gland saccule vas deferens fossa condyle otic vesicle ankle otic placode triceps brachii muscle temporal muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleic acid binding RNA binding Cellular component U2-type spliceosomal complex nucleus U2 snRNP nucleoplasm Biological process regulation of transcription by RNA polymerase II viral genome replication regulation of DNA-templated transcription, elongation regulation of transcription, DNA-templated transcription, DNA-templated mRNA splicing, via spliceosome Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27336 72459 Ensembl ENSG00000102241 ENSMUSG00000067873 UniProt O43719 Q8BGC0 RefSeq (mRNA) NM_001163280 NM_014500 NM_028242 NM_029371 RefSeq (protein) NP_001156752 NP_055315 NP_082518 NP_083647 Location (UCSC) Chr X: 136.5 – 136.51 Mb Chr X: 56.1 – 56.11 Mb PubMed search [3] [4]
Wikidata
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Function

Whereas most DNA sequence-specific transcription factors increase the rate of initiation and interact with enhancer or promoter DNA, human immunodeficiency virus-1 (HIV-1) Tat predominantly stimulates elongation and interacts with the trans-acting responsive (TAR) RNA element. Tat is essential for HIV replication.^[6]

HTATSF1 has also been shown to be involved in intron retention, and is associated with splicing of mRNAs that encode ribosomal proteins.^[7] It is also associated with a naïve pluripotent state, although the relationship is complex and is strongly affected by other pluripotency factors such as Nanog and KLF2.^[7]

Interactions

HTATSF1 has been shown to interact with SUPT5H^[8] and GTF2F2.^[8]