Host cell factor C1

Host cell factor 1 (HCFC1, HCF1, or HCF-1), also known as VP16-accessory protein,^[5] is a protein that in humans is encoded by the HCFC1 gene.^[6][7]

HCFC1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4GO6, 4N39, 4N3A, 4N3B, 4N3C
Identifiers
Aliases	HCFC1, CFF, HCF-1, HCF1, HFC1, MRX3, PPP1R89, VCAF, HCF, Host cell factor C1, XLID3, MAHCX
External IDs	OMIM: 300019; MGI: 105942; HomoloGene: 3898; GeneCards: HCFC1; OMA:HCFC1 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq28 Start 153,947,557 bp[1] End 153,971,818 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X A7.3|X 37.52 cM Start 72,986,398 bp[2] End 73,009,963 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii parotid gland Skeletal muscle tissue of rectus abdominis ganglionic eminence anterior pituitary nipple ventricular zone body of uterus pylorus apex of heart Top expressed in genital tubercle tail of embryo epiblast ventricular zone mandibular prominence thymus ganglionic eminence fetal liver hematopoietic progenitor cell maxillary prominence somite More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity transcription coactivator activity chromatin binding histone acetyltransferase activity (H4-K8 specific) histone acetyltransferase activity (H4-K5 specific) DNA-binding transcription activator activity, RNA polymerase II-specific protein binding identical protein binding histone acetyltransferase activity (H4-K16 specific) cadherin binding protein-macromolecule adaptor activity sequence-specific double-stranded DNA binding Cellular component cytoplasm membrane SAGA-type complex Set1C/COMPASS complex axon soma MLL1 complex dendrite histone acetyltransferase complex nucleus nucleoplasm protein-containing complex Biological process regulation of transcription, DNA-templated release from viral latency cellular response to organic cyclic compound protein stabilization mitochondrion organization negative regulation of transcription by RNA polymerase II histone H4-K5 acetylation positive regulation of gene expression positive regulation of cell cycle cell cycle histone H4-K16 acetylation viral process histone H4-K8 acetylation regulation of protein-containing complex assembly positive regulation of transcription by RNA polymerase II transcription by RNA polymerase II protein deubiquitination blastocyst hatching chromatin organization positive regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3054 15161 Ensembl ENSG00000172534 ENSMUSG00000031386 UniProt P51610 Q61191 RefSeq (mRNA) NM_005334 NM_008224 RefSeq (protein) NP_005325 NP_032250 Location (UCSC) Chr X: 153.95 – 153.97 Mb Chr X: 72.99 – 73.01 Mb PubMed search [3] [4]
Wikidata
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Structure

HCF1 is a member of the highly conserved host cell factor family and encodes a protein with five Kelch repeats, a fibronectin-like motif, and six HCF repeats, each of which contains a highly specific cleavage signal. This nuclear transcription coregulator is proteolytically cleaved at one or more of the six possible sites, resulting in the creation of an N-terminal chain and the corresponding C-terminal chain. The final form of this protein consists of noncovalently bound N- and C-terminal chains which interact through electrostatic forces.

Function

HCF1 is involved in control of the cell cycle as well as having regulatory roles in a multitude of processes related to transcription. Additionally, work in model organisms point to HCF1 as being a putative longevity determinant.^[8] Alternatively spliced variants that encode different protein isoforms have been described; however, not all variants have been fully characterized.^[7]

Mutations in this gene have been linked to disorders of the cobalamine metabolism.^[9]

Interactions

Host cell factor C1 has been shown to interact with:

• BAP1,^[10]
• CREB3,^[11][12]
• GABPA,^[13]
• HDAC1,^[14]
• HDAC2,^[14]
• MLL,^[15]
• OGT,^[14]
• PDCD2,^[16]
• POU2F1,^[17][18]
• PPP1CA,^[19]
• SIN3A,^[14][15]
• SP1,^[14][20]
• SUDS3,^[14]
• WDR5,^[14][15] and
• ZBTB17.^[21]