Hippocalcin

Hippocalcin is a protein that in humans is encoded by the HPCA gene.^[5][6]

HPCA
Identifiers
Aliases	HPCA, BDR2, DYT2, hippocalcin
External IDs	OMIM: 142622; MGI: 1336200; HomoloGene: 55634; GeneCards: HPCA; OMA:HPCA - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p35.1 Start 32,885,994 bp[1] End 32,898,441 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D2.2 Start 129,005,363 bp[2] End 129,015,829 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in caudate nucleus middle frontal gyrus putamen nucleus accumbens external globus pallidus prefrontal cortex right frontal lobe Region I of hippocampus proper Brodmann area 10 dorsolateral prefrontal cortex Top expressed in CA3 field dentate gyrus of hippocampal formation granule cell superior frontal gyrus olfactory tubercle primary visual cortex hippocampus proper Region I of hippocampus proper nucleus accumbens perirhinal cortex globus pallidus More reference expression data BioGPS n/a
Gene ontology Molecular function metal ion binding actin binding calcium ion binding identical protein binding kinase binding Cellular component perikaryon dendrite membrane neuronal cell body membrane axon dendritic spine head dendrite cytoplasm cytosol extrinsic component of membrane cytoplasm membrane postsynapse glutamatergic synapse Biological process positive regulation of adenylate cyclase activity response to organic cyclic compound cellular response to monosodium glutamate negative regulation of guanylate cyclase activity positive regulation of phospholipase activity activation of phospholipase D activity brain development retina development in camera-type eye response to ketamine response to L-glutamate inner ear development response to Aroclor 1254 calcium-mediated signaling positive regulation of protein targeting to membrane cellular response to electrical stimulus cellular response to calcium ion regulation of voltage-gated calcium channel activity regulation of postsynaptic neurotransmitter receptor internalization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3208 15444 Ensembl ENSG00000121905 ENSMUSG00000028785 UniProt P84074 P84075 RefSeq (mRNA) NM_002143 NM_001130419 NM_010471 NM_001286081 NM_001286083 RefSeq (protein) NP_002134 NP_001123891 NP_001273010 NP_001273012 NP_034601 Location (UCSC) Chr 1: 32.89 – 32.9 Mb Chr 4: 129.01 – 129.02 Mb PubMed search [3] [4]
Wikidata
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Hippocalcin is a calcium-binding protein that belongs to the neuronal calcium sensor (NCS) family of proteins.^[7][8] It is expressed in mammalian brains especially in the hippocampus. It possesses a Ca²⁺/myristoyl switch.^[9]

Processes

Hippocalcin takes part in the following processes:

• Activation of PLD1 and PLD2 expression
• Inhibition of apoptosis
• MAP kinase signalling
• Involved in long term depression in hippocampal neuron
• Required for normal spatial learning

Interactions

Hippocalcin interacts with following proteins:

• Neuronal apoptosis inhibitory protein (NAIP)
• Mixed lineage kinase 2 (MLK2) – MLK2 is myosin light chain kinase 2
• The b2 adaptin of the AP2 complex
• Calcium-dependent activator protein for secretion (CADPS)