IQSEC1

IQ motif and SEC7 domain-containing protein 1 also known as ARF-GEP₁₀₀ (ADP-Ribosylation Factor - Guanine nucleotide-Exchange Protein - 100-kDa) is a protein that in humans is encoded by the IQSEC1 gene.^[5][6]

IQSEC1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3QWM, 4C0A
Identifiers
Aliases	IQSEC1, ARF-GEP100, ARFGEP100, BRAG2, GEP100, IQ motif and Sec7 domain 1, IQ motif and Sec7 domain ArfGEF 1, IDDSSBA
External IDs	OMIM: 610166; MGI: 1196356; HomoloGene: 82429; GeneCards: IQSEC1; OMA:IQSEC1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p25.2-p25.1 Start 12,897,043 bp[1] End 13,283,281 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 D1|6 40.16 cM Start 90,633,070 bp[2] End 90,965,667 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 46 postcentral gyrus superior frontal gyrus right frontal lobe prefrontal cortex cingulate gyrus anterior cingulate cortex Brodmann area 9 middle temporal gyrus primary visual cortex Top expressed in granulocyte primary visual cortex superior frontal gyrus dentate gyrus of hippocampal formation granule cell neural layer of retina cerebellar cortex yolk sac pontine nuclei deep cerebellar nuclei central gray substance of midbrain More reference expression data BioGPS More reference expression data
Gene ontology Molecular function guanyl-nucleotide exchange factor activity lipid binding protein binding Cellular component cytoplasm membrane nucleus nucleolus intracellular membrane-bounded organelle Biological process positive regulation of GTPase activity regulation of ARF protein signal transduction actin cytoskeleton organization positive regulation of keratinocyte migration positive regulation of adherens junction organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9922 232227 Ensembl ENSG00000144711 ENSMUSG00000034312 UniProt Q6DN90 Q8R0S2 RefSeq (mRNA) NM_001134382 NM_014869 NM_001330619 NM_001376938 NM_001134383 NM_001134384 NM_182784 NM_001356440 RefSeq (protein) NP_001127854 NP_001317548 NP_055684 NP_001363867 NP_001127855 NP_001127856 NP_001343369 Location (UCSC) Chr 3: 12.9 – 13.28 Mb Chr 6: 90.63 – 90.97 Mb PubMed search [3] [4]
Wikidata
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Function

The ARF-GEP₁₀₀ protein is involved in signal transduction. It is a guanine nucleotide exchange factor that promotes binding of GTP to ADP ribosylation factor protein ARF6 and to a lesser extent ARF1 and ARF5.^[6] This activates the ADP-ribosylation activity of the target protein and cause it to modify its substrates. ARF-GEP₁₀₀, through activation of ARF6, is therefore involved in the control of processes such as endocytosis of plasma membrane proteins, E-cadherin recycling and actin cytoskeleton remodeling.^[7] ARF-GEP₁₀₀ appears particularly important in regulating cell adhesion, with reductions in the level of this protein causing enhanced spreading and attachment of cells.^[8]

It is highly expressed in the prefrontal cortex, and throughout the rest of the brain, and is believed to have a role in learning and memory, having been detected as phosphorylated in a phospho screen of the PSD.^[9]