MCM3AP

80 kDa MCM3-associated protein is a protein that in humans is encoded by the MCM3AP gene.^[5][6]

MCM3AP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4DHX
Identifiers
Aliases	MCM3AP, GANP, MAP80, SAC3, minichromosome maintenance complex component 3 associated protein, PNRIID
External IDs	OMIM: 603294; MGI: 1930089; HomoloGene: 2902; GeneCards: MCM3AP; OMA:MCM3AP - orthologs
Gene location (Human) Chr. Chromosome 21 (human)[1] Band 21q22.3 Start 46,235,133 bp[1] End 46,286,297 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 C1 Start 76,304,761 bp[2] End 76,351,691 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii tibial nerve right uterine tube gastrocnemius muscle body of uterus gastric mucosa right ovary right lobe of thyroid gland cerebellar hemisphere right hemisphere of cerebellum Top expressed in saccule otic vesicle zygote primary oocyte otic placode secondary oocyte Rostral migratory stream granulocyte renal corpuscle ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity DNA binding acyltransferase activity nucleic acid binding chromatin binding histone acetyltransferase activity protein binding H3 histone acetyltransferase activity histone binding Cellular component cytosol nuclear pore nuclear membrane nuclear envelope nucleus nucleoplasm cytoplasm transcription export complex 2 nuclear pore nuclear basket chromosome Biological process protein transport mRNA transport protein import into nucleus immune system process transport mRNA export from nucleus poly(A)+ mRNA export from nucleus somatic hypermutation of immunoglobulin genes histone acetylation nucleosome organization histone H3 acetylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8888 54387 Ensembl ENSG00000160294 ENSMUSG00000001150 UniProt O60318 Q9WUU9 RefSeq (mRNA) NM_003906 NM_019434 RefSeq (protein) NP_003897 NP_062307 Location (UCSC) Chr 21: 46.24 – 46.29 Mb Chr 10: 76.3 – 76.35 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The minichromosome maintenance protein 3 (MCM3) is one of the MCM proteins essential for the initiation of DNA replication. The protein encoded by this gene is an MCM3 binding protein. It was reported to have phosphorylation-dependent DNA-primase activity, which was up-regulated in antigen immunization induced germinal center. This protein was demonstrated to be an acetyltransferase that acetylates MCM3 and plays a role in DNA replication. The mutagenesis of a nuclear localization signal of MCM3 affects the binding of this protein with MCM3, suggesting that this protein may also facilitate MCM3 nuclear localization.^[6]

Interactions

MCM3AP has been shown to interact with:

• MCM3^[5][7][8] and
• TRIB3.^[9]