MRVI1

Protein MRVI1 is a protein that in humans is encoded by the MRVI1 gene.^[5][6]

IRAG1
Identifiers
Aliases	IRAG1, IRAG, JAW1L, murine retrovirus integration site 1 homolog, MRVI1, inositol 1,4,5-triphosphate receptor associated 1
External IDs	OMIM: 604673; MGI: 1338023; HomoloGene: 4425; GeneCards: IRAG1; OMA:IRAG1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.4 Start 10,573,091 bp[1] End 10,693,988 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 E3|7 57.9 cM Start 110,467,473 bp[2] End 110,581,668 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in saphenous vein urethra right coronary artery ascending aorta vena cava popliteal artery tibial arteries Descending thoracic aorta external globus pallidus cardia Top expressed in ascending aorta iris aortic valve uterus vas deferens tunica media of zone of aorta blood Paneth cell conjunctival fornix cervix More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cytoplasm perinuclear region of cytoplasm integral component of membrane platelet dense tubular network membrane endoplasmic reticulum membrane membrane sarcoplasmic reticulum Biological process blood coagulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10335 17540 Ensembl ENSG00000072952 ENSMUSG00000005611 UniProt Q9Y6F6 Q9WUX5 RefSeq (mRNA) NM_130385 NM_001098579 NM_001100163 NM_001100167 NM_001206880 NM_001206881 NM_010826 NM_194464 RefSeq (protein) NP_001092049 NP_001093633 NP_001093637 NP_001193809 NP_001193810 NP_569056 NP_034956 NP_919446 Location (UCSC) Chr 11: 10.57 – 10.69 Mb Chr 7: 110.47 – 110.58 Mb PubMed search [3] [4]
Wikidata
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Function

This gene is similar to a mouse putative tumor suppressor gene that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is downregulated during myeloid differentiation. Therefore, this gene may be a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcripts have been found for this gene, however, the full-length nature of some variants has not been determined. Of the two characterized variants which encode different isoforms, one initiates translation at a non-AUG start site.^[6]

Interactions

MRVI1 has been shown to interact with ITPR1^[7] and PRKG1.^[7][8]