ITPR1

Inositol 1,4,5-trisphosphate receptor type 1 is a protein that in humans is encoded by the ITPR1 gene.^{[5][6][7][8][9]}

ITPR1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1N4K, 1XZZ
Identifiers
Aliases	ITPR1, ACV, CLA4, INSP3R1, IP3R, IP3R1, PPP1R94, SCA15, SCA16, SCA29, inositol 1,4,5-trisphosphate receptor type 1
External IDs	OMIM: 147265; MGI: 96623; HomoloGene: 1673; GeneCards: ITPR1; OMA:ITPR1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p26.1 Start 4,493,345 bp[1] End 4,847,506 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 E1- E2|6 49.74 cM Start 108,190,057 bp[2] End 108,528,070 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tail of epididymis Brodmann area 23 primary visual cortex right coronary artery popliteal artery tibial arteries seminal vesicula right hemisphere of cerebellum orbitofrontal cortex left coronary artery Top expressed in cerebellar vermis lobe of cerebellum olfactory tubercle vestibular membrane of cochlear duct primary motor cortex Epithelium of choroid plexus cingulate gyrus Region I of hippocampus proper superior frontal gyrus choroid plexus of fourth ventricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium channel inhibitor activity calcium channel activity inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity calcium ion transmembrane transporter activity ion channel activity protein binding phosphatidylinositol binding calcium-release channel activity calcium ion binding inositol 1,4,5 trisphosphate binding inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels Cellular component cytoplasm integral component of membrane platelet dense tubular network endoplasmic reticulum membrane membrane postsynaptic density nuclear envelope calcineurin complex sarcoplasmic reticulum nuclear inner membrane platelet dense granule membrane nucleolus platelet dense tubular network membrane plasma membrane transport vesicle membrane cytoplasmic vesicle perinuclear region of cytoplasm endoplasmic reticulum cytoplasmic vesicle membrane secretory granule membrane protein-containing complex Schaffer collateral - CA1 synapse Biological process release of sequestered calcium ion into cytosol regulation of cardiac conduction response to hypoxia voluntary musculoskeletal movement regulation of insulin secretion epithelial fluid transport ion transport post-embryonic development endoplasmic reticulum calcium ion homeostasis platelet activation intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress regulation of autophagy transmembrane transport calcium ion transmembrane transport negative regulation of calcium-mediated signaling inositol phosphate-mediated signaling calcium ion transport apoptotic process signal transduction regulation of molecular function transport regulation of postsynaptic cytosolic calcium ion concentration Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3708 16438 Ensembl ENSG00000150995 ENSMUSG00000030102 UniProt Q14643 P11881 RefSeq (mRNA) NM_001099952 NM_001168272 NM_002222 NM_001378452 NM_010585 RefSeq (protein) NP_001093422 NP_001161744 NP_002213 NP_034715 Location (UCSC) Chr 3: 4.49 – 4.85 Mb Chr 6: 108.19 – 108.53 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

ITPR1 has been shown to interact with:

• AHCYL1,^[10]
• CA8,^[11]
• EPB41L1^[12]
• FKBP1A,^[13][14]
• MRVI1,^[15]
• PRKG1,^[15]
• RHOA,^[16] and
• TRPC4.^[17][18]

• Caspr2, ^[19]

See also

• Inositol triphosphate
• Inositol triphosphate receptor