PRKG1

cGMP-dependent protein kinase 1, alpha isozyme is an enzyme that in humans is encoded by the PRKG1 gene.^[5][6][7]

PRKG1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ZXA, 3OCP, 3OD0, 3OGJ, 4KU7, 4KU8, 4QX5, 4QXK, 4R4L, 4R4M, 4Z07
Identifiers
Aliases	PRKG1, AAT8, PKG, PRKG1B, PRKGR1B, cGK, cGK 1, cGK1, cGKI, cGKI-BETA, cGKI-alpha, protein kinase, cGMP-dependent, type I, PKG1, protein kinase cGMP-dependent 1
External IDs	OMIM: 176894; MGI: 108174; HomoloGene: 55964; GeneCards: PRKG1; OMA:PRKG1 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q11.23-q21.1 Start 50,990,888 bp[1] End 52,298,423 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 C1 Start 30,541,889 bp[2] End 31,742,433 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in saphenous vein biceps brachii Skeletal muscle tissue of biceps brachii Descending thoracic aorta ascending aorta Skeletal muscle tissue of rectus abdominis right coronary artery popliteal artery urethra tibial arteries Top expressed in spermatid lumbar spinal ganglion epithelium of lens trigeminal ganglion soleus muscle sternocleidomastoid muscle digastric muscle temporal muscle intercostal muscle zygote More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding calcium channel regulator activity cGMP binding kinase activity protein binding catalytic activity ATP binding protein serine/threonine kinase activity cGMP-dependent protein kinase activity identical protein binding protein kinase activity Cellular component cytoplasm cytosol Golgi apparatus plasma membrane Biological process negative regulation of smooth muscle contraction phosphorylation regulation of GTPase activity dendrite development neuron migration negative regulation of platelet aggregation cGMP-mediated signaling relaxation of vascular associated smooth muscle forebrain development metabolism actin cytoskeleton organization signal transduction protein phosphorylation negative regulation of vascular associated smooth muscle cell proliferation negative regulation of vascular associated smooth muscle cell migration Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5592 19091 Ensembl ENSG00000185532 ENSMUSG00000052920 UniProt Q13976 P0C605 RefSeq (mRNA) NM_001098512 NM_006258 NM_001374781 NM_001374782 NM_001013833 NM_011160 RefSeq (protein) NP_001091982 NP_006249 NP_001361710 NP_001361711 NP_001013855 NP_035290 Location (UCSC) Chr 10: 50.99 – 52.3 Mb Chr 19: 30.54 – 31.74 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

PRKG1 has been shown to interact with:

• GTF2I,^[8]
• ITPR1,^[9]
• MRVI1,^[9][10]
• RGS2,^[11] and
• TNNT1.^[12]