NBPF10

Neuroblastoma breakpoint family member 10 is a protein that in Homo sapiens is encoded by the NBPF10 gene.^[3][4]

NBPF20
Identifiers
Aliases	NBPF20, NBPF member 20
External IDs	OMIM: 614007; HomoloGene: 41035; GeneCards: NBPF20; OMA:NBPF20 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.1 Start 145,289,900 bp[1] End 145,405,567 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve cerebellar cortex cerebellar hemisphere right hemisphere of cerebellum testicle stromal cell of endometrium tonsil bone marrow cell liver gonad n/a More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 100288142 n/a Ensembl ENSG00000162825 n/a UniProt P0DPF3 P0DPF2 n/a RefSeq (mRNA) NM_001278267 NM_001397211 n/a RefSeq (protein) NP_001032764 NP_001264373 NP_001265196 n/a Location (UCSC) Chr 1: 145.29 – 145.41 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

The full gene is 75,313 bp, with the major isoform of mRNA being 10,697 bp long. The gene is located at 1q21.1. NBPF contains what is known as the DUF1220 repeats. The highly conserved, repeated region is believed to be originated from MGC8902. The NBPF family has been linked to primate evolution.^[4] It is assumed to be related to the 1q21.1 deletion syndrome and 1q21.1 duplication syndrome.^[5]

Homology

Paralogs of NBPF10 includes other NBPF family members. Orthologs of NBPF10 are found in other primates; distant orthologs are found in bovine, equine, and canine

Functional role

Although NBPF10's function is unknown, there is reason to believe that NBPF10 is an important biomarker for the Odontoblast Phenotype^[6]

Gene Neighborhood

NOTCH2NL, SEC22B, HFE2, TXNIP are close neighbors of NBPF10. All of these neighboring genes are well studied in their own right.

Post-translational modification

NBPF10 has extremely low threonine content which may make the protein less susceptible to post-translational modification.^{[citation needed]}