SEC22B

Vesicle-trafficking protein SEC22b is a protein that in humans is encoded by the SEC22B gene.^[5][6][7]

SEC22B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2NUP, 2NUT, 3EGD, 3EGX
Identifiers
Aliases	SEC22B, ERS-24, SEC22L1, SEC22 homolog B, vesicle trafficking protein (gene/pseudogene), SEC22 homolog B, vesicle trafficking protein
External IDs	OMIM: 604029; MGI: 1338759; HomoloGene: 3597; GeneCards: SEC22B; OMA:SEC22B - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p12 Start 120,150,898 bp[1] End 120,176,520 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F2.2 Start 97,808,506 bp[2] End 97,830,592 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon body of pancreas islet of Langerhans stromal cell of endometrium anterior pituitary epithelium of colon rectum monocyte left adrenal gland Descending thoracic aorta Top expressed in cumulus cell endocardial cushion neural layer of retina yolk sac molar lacrimal gland islet of Langerhans calvaria primitive streak seminal vesicula More reference expression data BioGPS n/a
Gene ontology Molecular function SNAP receptor activity protein binding syntaxin binding SNARE binding Cellular component integral component of membrane Golgi apparatus endoplasmic reticulum membrane membrane melanosome endoplasmic reticulum endoplasmic reticulum-Golgi intermediate compartment membrane endoplasmic reticulum-Golgi intermediate compartment SNARE complex Golgi membrane transport vesicle phagocytic vesicle membrane ER to Golgi transport vesicle membrane synaptic vesicle Biological process positive regulation of protein catabolic process vesicle fusion with Golgi apparatus COPII vesicle coating protein transport vesicle-mediated transport exocytosis retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent endoplasmic reticulum to Golgi vesicle-mediated transport vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane negative regulation of autophagosome assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9554 20333 Ensembl ENSG00000265808 ENSMUSG00000027879 UniProt O75396 O08547 RefSeq (mRNA) NM_004892 NM_011342 RefSeq (protein) NP_004883 NP_035472 Location (UCSC) Chr 1: 120.15 – 120.18 Mb Chr 3: 97.81 – 97.83 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a member of the SEC22 family of vesicle trafficking proteins. It associates with other SNARE proteins to form a SNARE complex and it is thought to play a role in the ER-Golgi protein trafficking. It is required for platelet alpha-granule biogenesis in megakaryocytes^[8] and is essential for the elongated morphology of endothelial cell Weibel-Palade bodies.^[9] This protein has strong similarity to Mus musculus and Cricetulus griseus proteins. There is evidence for use of multiple polyadenylation sites for the transcript.^[7] SEC22B has been shown to interact with syntaxin 18^[10] and syntaxin 5.^[11]