Nuclear receptor coactivator 2

The nuclear receptor coactivator 2 also known as NCoA-2 is a protein that in humans is encoded by the NCOA2 gene. NCoA-2 is also frequently called glucocorticoid receptor-interacting protein 1 (GRIP1), steroid receptor coactivator-2 (SRC-2), or transcriptional mediators/intermediary factor 2 (TIF2).

NCOA2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1GWQ, 1GWR, 1M2Z, 1MV9, 1MVC, 1MZN, 1P93, 1T63, 1T65, 1UHL, 1YOK, 1ZDT, 1ZDU, 1ZKY, 2AO6, 2B1V, 2B1Z, 2B23, 2FAI, 2G44, 2G5O, 2P15, 2P1T, 2P1U, 2P1V, 2Q7J, 2Q7L, 2ZXZ, 2ZY0, 3A9E, 3DZU, 3DZY, 3E00, 3E7C, 3E94, 3FUG, 3GN8, 3K23, 3KWY, 3KYT, 3L0E, 3L0L, 3O1D, 3O1E, 3OAP, 3OZJ, 3PCU, 3PLZ, 3Q95, 3Q97, 3R5M, 3UP0, 3UP3, 4DOS, 4E2J, 4FHH, 4FHI, 4IA1, 4IA2, 4IA3, 4IA7, 4IQR, 4IU7, 4IUI, 4IV2, 4IV4, 4IVW, 4IVY, 4IW6, 4IW8, 4IWC, 4IWF, 2LDC, 2YJD, 3CLD, 3ERD, 3K22, 4CSJ, 4K4J, 4K6I, 4M8E, 4M8H, 4NIE, 4NQA, 4OC7, 4P6W, 4P6X, 4POH, 4POJ, 4PP3, 4PP5, 4PP6, 4PPP, 4PPS, 4PXM, 4Q0A, 4WG0, 4QE6, 4QE8, 4RFW, 4RMC, 4RMD, 4RME, 4ZN9, 4ZO1, 4RUO, 5APJ, 4UDD, 4PLD, 4PLE, 4UDC, 5APH, 5DMC, 5DKB, 5DMF, 4ZNV, 5DVS, 5DL4, 5E0W, 5E19, 4ZUC, 5DI7, 5I4V, 5E0X, 5E1C, 4ZWK, 5DYD, 5DIG, 5DKG, 5DTV, 5EC9, 5DX3, 5DRM, 5BP6, 5DYB, 5DLR, 5E14, 5DXK, 5DUH, 5DVV, 5DU5, 5DXP, 5DP0, 4ZNS, 5DZ3, 5DXR, 5DXQ, 5DZI, 4ZNT, 4ZNW, 5DID, 5DXM, 5EHJ, 5BQ4, 5DY8, 4ZSH, 5DXB, 5DUG, 5DK9, 5EIT, 5BPR, 5DWJ, 5DWI, 5HYR, 5DKS, 4ZUB, 5EI1, 5DZ0, 4ZNU, 4ZNH, 5E15, 4ZN7, 5DZ1, 5DUE, 4ZWH, 5EGV, 5BNU, 5DIE, 5DKE, 5DWG, 5DZH, 5DRJ, 5DWE
Identifiers
Aliases	NCOA2, GRIP1, KAT13C, NCoA-2, SRC2, TIF2, bHLHe75, nuclear receptor coactivator 2
External IDs	OMIM: 601993; MGI: 1276533; HomoloGene: 4768; GeneCards: NCOA2; OMA:NCOA2 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q13.3 Start 70,109,782 bp[1] End 70,403,808 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 A3|1 4.12 cM Start 13,139,105 bp[2] End 13,374,083 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus epididymis endothelial cell secondary oocyte seminal vesicula jejunal mucosa amniotic fluid tibia Epithelium of choroid plexus buccal mucosa cell oral cavity Top expressed in substantia nigra lacrimal gland ciliary body left lung lobe retinal pigment epithelium lateral geniculate nucleus habenula median eminence lobe of cerebellum cerebellar vermis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein dimerization activity transcription coactivator activity transcription factor binding chromatin binding RNA polymerase II cis-regulatory region sequence-specific DNA binding protein binding nuclear receptor coactivator activity RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding signaling receptor binding nuclear receptor binding aryl hydrocarbon receptor binding protein domain specific binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytoplasm nucleoplasm nucleus nuclear body protein-containing complex Biological process regulation of transcription, DNA-templated cellular response to Thyroglobulin triiodothyronine rhythmic process negative regulation of transcription by RNA polymerase II circadian regulation of gene expression transcription, DNA-templated cellular response to hormone stimulus regulation of glucose metabolic process circadian rhythm bile acid and bile salt transport negative regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II locomotor rhythm intracellular receptor signaling pathway regulation of lipid metabolic process regulation of gene expression response to progesterone Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10499 17978 Ensembl ENSG00000140396 ENSMUSG00000005886 UniProt Q15596 Q61026 RefSeq (mRNA) NM_006540 NM_001321703 NM_001321707 NM_001321711 NM_001321712 NM_001321713 NM_001077695 NM_008678 NM_001302702 RefSeq (protein) NP_001308632 NP_001308636 NP_001308640 NP_001308641 NP_001308642 NP_006531 NP_001289631 NP_032704 Location (UCSC) Chr 8: 70.11 – 70.4 Mb Chr 1: 13.14 – 13.37 Mb PubMed search [3] [4]
Wikidata
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Function

NCoA-2 is a transcriptional coregulatory protein that contains several nuclear receptor interacting domains and an intrinsic histone acetyltransferase activity. NCOA2 is recruited to DNA promotion sites by ligand-activated nuclear receptors. NCOA2 in turn acetylates histones, which makes downstream DNA more accessible to transcription. Hence, NCOA2 assists nuclear receptors in the upregulation of DNA expression.^[5][6]

GRIP1 is a transcriptional co-activator of the glucocorticoid receptor and interferon regulatory factor 1 (IRF1).^[7]

Interactions

Nuclear receptor coactivator 2 has been shown to interact with:

• AR,^{[8][9][10][11][12]}
• ARNT,^[13]
• BRCA1,^[14][15]
• ESR1,^[11][16][17]
• NR3C1,^[18][19]
• PPFIA4,^[20]
• RXRA,^[21][22]
• VDR.^[11][21][23]