PAPSS1

Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 is an enzyme that in humans is encoded by the PAPSS1 gene.^[5][6][7]

PAPSS1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1X6V, 1XJQ, 1XNJ, 2OFW, 2OFX, 2PEY, 2PEZ, 2QJF
Identifiers
Aliases	PAPSS1, ATPSK1, PAPSS, SK1, 3'-phosphoadenosine 5'-phosphosulfate synthase 1
External IDs	OMIM: 603262; MGI: 1330587; HomoloGene: 81740; GeneCards: PAPSS1; OMA:PAPSS1 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q25 Start 107,590,276 bp[1] End 107,720,234 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 G3|3 61.05 cM Start 131,270,529 bp[2] End 131,349,432 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in inferior ganglion of vagus nerve secondary oocyte Pons bronchial epithelial cell subthalamic nucleus pylorus corpus callosum endometrium superior vestibular nucleus Brodmann area 46 Top expressed in vestibular membrane of cochlear duct left colon submandibular gland vestibular sensory epithelium lacrimal gland migratory enteric neural crest cell medullary collecting duct ileum human fetus utricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding nucleotidyltransferase activity catalytic activity ATP binding kinase activity sulfate adenylyltransferase (ATP) activity protein homodimerization activity adenylylsulfate kinase activity Cellular component cytosol Biological process skeletal system development metabolism phosphorylation sulfate assimilation 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9061 23971 Ensembl ENSG00000138801 ENSMUSG00000028032 UniProt O43252 Q60967 RefSeq (mRNA) NM_005443 NM_001289477 NM_001289478 NM_001289479 NM_011863 RefSeq (protein) NP_005434 NP_001276406 NP_001276407 NP_001276408 NP_035993 Location (UCSC) Chr 4: 107.59 – 107.72 Mb Chr 3: 131.27 – 131.35 Mb PubMed search [3] [4]
Wikidata
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Three-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS) is the sulfate donor cosubstrate for all sulfotransferase (SULT) enzymes (Xu et al., 2000). SULTs catalyze the sulfate conjugation of many endogenous and exogenous compounds, including drugs and other xenobiotics. In humans, PAPS is synthesized from adenosine 5-prime triphosphate (ATP) and inorganic sulfate by 2 isoforms, PAPSS1 and PAPSS2 (MIM 603005).[supplied by OMIM]^[7]