Protein kinase N1

Serine/threonine-protein kinase N1 is an enzyme that in humans is encoded by the PKN1 gene.^[5][6]

PKN1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1CXZ, 1URF, 2RMK, 4NKG, 4OTD, 4OTG, 4OTH, 4OTI
Identifiers
Aliases	PKN1, DBK, PAK-1, PAK1, PKN, PKN-ALPHA, PRK1, PRKCL1, Protein kinase N1
External IDs	OMIM: 601032; MGI: 108022; HomoloGene: 48130; GeneCards: PKN1; OMA:PKN1 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.12 Start 14,433,053 bp[1] End 14,471,867 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 C2|8 40.22 cM Start 84,393,165 bp[2] End 84,425,808 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart granulocyte ventricular zone right lung stromal cell of endometrium muscle of thigh ganglionic eminence monocyte upper lobe of left lung gastric mucosa Top expressed in granulocyte thymus muscle of thigh superior frontal gyrus external carotid artery ventricular zone right ventricle primary visual cortex right kidney internal carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity protein kinase activity nucleotide binding protein kinase C activity histone binding histone deacetylase binding chromatin binding histone kinase activity (H3-T11 specific) kinase activity protein serine/threonine kinase activity protein binding androgen receptor binding nuclear receptor coactivator activity ATP binding protein kinase C binding Cellular component cytoplasm cytosol endosome membrane plasma membrane nucleoplasm midbody cleavage furrow nucleus cytoplasmic vesicle protein-containing complex Biological process regulation of germinal center formation negative regulation of protein phosphorylation renal system process regulation of transcription, DNA-templated B cell apoptotic process negative regulation of protein kinase activity phosphorylation regulation of transcription by RNA polymerase II B cell homeostasis spleen development hyperosmotic response transcription, DNA-templated regulation of cell motility protein phosphorylation peptidyl-serine phosphorylation epithelial cell migration negative regulation of B cell proliferation regulation of immunoglobulin production signal transduction chromatin organization positive regulation of nucleic acid-templated transcription intracellular signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5585 320795 Ensembl ENSG00000123143 ENSMUSG00000057672 UniProt Q16512 P70268 RefSeq (mRNA) NM_002741 NM_213560 NM_001199593 NM_177262 RefSeq (protein) NP_002732 NP_998725 NP_001186522 NP_796236 Location (UCSC) Chr 19: 14.43 – 14.47 Mb Chr 8: 84.39 – 84.43 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed.^[6]

Interactions

Protein kinase N1 has been shown to interact with:

• AKAP9,^[7]
• Actinin, alpha 1,^[8]
• CCDC85B,^[9]
• NEFL,^[10]
• NEUROD2^[11]
• Phosphoinositide-dependent kinase-1,^[12]
• Phospholipase D1,^[13]
• RHOA,^[14][15][16] and
• Vimentin.^[17]
• TRAF1.^[18]