POLR1C

DNA-directed RNA polymerases I and III subunit RPAC1 is a protein that in humans is encoded by the POLR1C gene.^[5][6][7]

POLR1C
Identifiers
Aliases	POLR1C, RPA39, RPA40, RPA5, RPAC1, TCS3, AC40, RPC40, HLD11, polymerase (RNA) I subunit C, RNA polymerase I subunit C, RNA polymerase I and III subunit C
External IDs	OMIM: 610060; MGI: 103288; HomoloGene: 3586; GeneCards: POLR1C; OMA:POLR1C - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.1 Start 43,509,702 bp[1] End 43,562,419 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 C Start 46,554,846 bp[2] End 46,558,980 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte sperm pancreatic ductal cell Achilles tendon gonad islet of Langerhans right uterine tube stromal cell of endometrium right lobe of thyroid gland epithelium of nasopharynx Top expressed in primitive streak medullary collecting duct renal corpuscle ureter fossa condyle medial ganglionic eminence maxillary prominence mandibular prominence hair follicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein dimerization activity RNA polymerase III activity DNA-directed 5'-3' RNA polymerase activity protein binding RNA polymerase I activity Cellular component cytosol nucleoplasm RNA polymerase III complex nucleus RNA polymerase I complex Biological process transcription by RNA polymerase I termination of RNA polymerase I transcription epigenetic maintenance of chromatin in transcription-competent conformation transcription initiation from RNA polymerase I promoter transcription, DNA-templated transcription by RNA polymerase III transcription elongation from RNA polymerase I promoter positive regulation of type I interferon production Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9533 20016 Ensembl ENSG00000171453 ENSMUSG00000067148 UniProt O15160 P52432 RefSeq (mRNA) NM_004875 NM_203290 NM_001318876 NM_001363658 NM_009085 RefSeq (protein) NP_001305805 NP_976035 NP_001350587 NP_033111 Location (UCSC) Chr 6: 43.51 – 43.56 Mb Chr 17: 46.55 – 46.56 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

POLR1C has been shown to interact with CD3EAP,^[8] POLR1E^[8][9][10] and POLR1D.^[11][12]