POLR1E

DNA-directed RNA polymerase I subunit RPA49 is an enzyme that in humans is encoded by the POLR1E gene.^[5][6]

POLR1E
Identifiers
Aliases	POLR1E, PAF53, PRAF1, polymerase (RNA) I subunit E, RNA polymerase I subunit E, A49, RPA49
External IDs	MGI: 1929022; HomoloGene: 41486; GeneCards: POLR1E; OMA:POLR1E - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9p13.2 Start 37,485,948 bp[1] End 37,503,697 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 B1 Start 45,018,583 bp[2] End 45,036,565 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas left ovary Achilles tendon gonad body of uterus right ovary secondary oocyte ganglionic eminence ectocervix left uterine tube Top expressed in otic placode saccule embryo otic vesicle spermatocyte morula epiblast embryo tail of embryo primitive streak More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-directed 5'-3' RNA polymerase activity DNA binding RNA polymerase I general transcription initiation factor binding RNA polymerase I activity Cellular component nucleus nucleoplasm fibrillar center nucleolus RNA polymerase I complex Biological process transcription initiation from RNA polymerase I promoter termination of RNA polymerase I transcription epigenetic maintenance of chromatin in transcription-competent conformation transcription, DNA-templated RNA polymerase I preinitiation complex assembly transcription elongation from RNA polymerase I promoter Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64425 64424 Ensembl ENSG00000137054 ENSMUSG00000028318 UniProt Q9GZS1 Q8K202 RefSeq (mRNA) NM_001282766 NM_022490 NM_001285800 NM_022811 RefSeq (protein) NP_001269695 NP_071935 NP_001272729 NP_073722 Location (UCSC) Chr 9: 37.49 – 37.5 Mb Chr 4: 45.02 – 45.04 Mb PubMed search [3] [4]
Wikidata
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Interactions

POLR1E has been shown to interact with CD3EAP^[7] and POLR1C.^[8][7][9]