RASSF5

Ras association domain-containing protein 5 is a protein that in humans is encoded by the RASSF5 or F5 gene.^[5][6][7]

RASSF5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4LGD, 4OH8
Identifiers
Aliases	RASSF5, Maxp1, NORE1, NORE1A, NORE1B, RAPL, RASSF3, Ras association domain family member 5
External IDs	OMIM: 607020; MGI: 1926375; HomoloGene: 10296; GeneCards: RASSF5; OMA:RASSF5 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q32.1 Start 206,507,531 bp[1] End 206,589,448 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 E4|1 56.91 cM Start 131,104,147 bp[2] End 131,172,995 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of arm blood granulocyte thymus mucosa of ileum lymph node monocyte bone marrow appendix nasal epithelium Top expressed in granulocyte thymus primary oocyte mesenteric lymph nodes spleen secondary oocyte blood motor neuron zygote endocardial cushion More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding metal ion binding identical protein binding Cellular component cytoplasm microtubule cytoskeleton nucleus Biological process intracellular signal transduction positive regulation of protein ubiquitination signal transduction negative regulation of cell population proliferation regulation of protein localization to nucleus apoptotic process regulation of apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 83593 54354 Ensembl ENSG00000266094 ENSMUSG00000026430 UniProt Q8WWW0 Q5EBH1 RefSeq (mRNA) NM_182665 NM_031437 NM_182663 NM_182664 NM_018750 NM_001311094 NM_001313731 RefSeq (protein) NP_872604 NP_872605 NP_872606 NP_001298023 NP_001300660 NP_061220 Location (UCSC) Chr 1: 206.51 – 206.59 Mb Chr 1: 131.1 – 131.17 Mb PubMed search [3] [4]
Wikidata
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Function

This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding different isoforms have been found for this gene.^[7]

Interactions

RASSF5 has been shown to interact with RRAS,^[8] RAP2A,^[8] MRAS^[8] and RASSF1.^[8]