RAP2A

Ras-related protein Rap-2a is a protein that in humans is encoded by the RAP2A gene.^[5] RAP2A is a member of the Ras-related protein family.

RAP2A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1KAO, 2RAP, 3RAP
Identifiers
Aliases	RAP2A, K-REV, KREV, RAP2, RbBP-30, member of RAS oncogene family
External IDs	OMIM: 179540; MGI: 97855; HomoloGene: 10875; GeneCards: RAP2A; OMA:RAP2A - orthologs
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q32.1 Start 97,434,169 bp[1] End 97,469,128 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 E4|14 64.72 cM Start 120,715,856 bp[2] End 120,744,606 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Pons buccal mucosa cell internal globus pallidus superior vestibular nucleus subthalamic nucleus Parietal Lobe middle temporal gyrus Brodmann area 23 inferior ganglion of vagus nerve postcentral gyrus Top expressed in sciatic nerve Region I of hippocampus proper subiculum left lung lobe ventromedial nucleus barrel cortex anterior amygdaloid area optic nerve nucleus of stria terminalis primary motor cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding protein binding magnesium ion binding GTPase activity GTP binding GDP binding Cellular component recycling endosome cytosol endosome membrane plasma membrane recycling endosome membrane midbody Biological process actin cytoskeleton reorganization microvillus assembly positive regulation of protein phosphorylation establishment of protein localization Rap protein signal transduction regulation of dendrite morphogenesis regulation of JNK cascade negative regulation of cell migration establishment of epithelial cell apical/basal polarity positive regulation of protein autophosphorylation protein localization to plasma membrane signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5911 76108 Ensembl ENSG00000125249 ENSMUSG00000051615 UniProt P10114 Q80ZJ1 RefSeq (mRNA) NM_021033 NM_029519 RefSeq (protein) NP_066361 NP_083795 Location (UCSC) Chr 13: 97.43 – 97.47 Mb Chr 14: 120.72 – 120.74 Mb PubMed search [3] [4]
Wikidata
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Interactions

RAP2A has been shown to interact with RUNDC3A,^[6] RASSF5^[7] and RALGDS.^[8]