SND1

Staphylococcal nuclease domain-containing protein 1 also known as 100 kDa coactivator or Tudor domain-containing protein 11 (TDRD11) is a protein that in humans is encoded by the SND1 gene.^[5][6][7][8] SND1 is a main component of RISC complex^[9] and plays an important role in miRNA function.^[10][11] SND1 is Tudor domain containing protein and Tudor Proteins are highly conserved proteins and even present in Drosophila melanogaster.^[12] SND1 is also involved in Autism.^[13]

SND1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2E6N, 2HQE, 2HQX, 2O4X, 3BDL, 3OMC, 3OMG, 4QMG
Identifiers
Aliases	SND1, TDRD11, p100, staphylococcal nuclease and tudor domain containing 1, Tudor-SN
External IDs	OMIM: 602181; MGI: 1929266; HomoloGene: 8665; GeneCards: SND1; OMA:SND1 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q32.1 Start 127,652,194 bp[1] End 128,092,609 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 A3.3 Start 28,475,138 bp[2] End 28,935,161 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas stromal cell of endometrium islet of Langerhans parotid gland epithelium of colon canal of the cervix left ovary smooth muscle tissue anterior pituitary right ovary Top expressed in lacrimal gland parotid gland dentate gyrus of hippocampal formation granule cell yolk sac lip epiblast ventricular zone molar stroma of bone marrow placenta More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding transcription coregulator activity nucleic acid binding nuclease activity RNA binding cadherin binding endonuclease activity endoribonuclease activity hydrolase activity RISC complex binding Cellular component melanosome RISC complex extracellular exosome mitochondrion membrane dense body cytoplasm cytosol nucleus Biological process gene silencing viral process regulation of transcription, DNA-templated osteoblast differentiation transcription, DNA-templated nucleic acid phosphodiester bond hydrolysis RNA catabolic process regulation of cell cycle process miRNA catabolic process RNA phosphodiester bond hydrolysis, endonucleolytic regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27044 56463 Ensembl ENSG00000197157 ENSMUSG00000001424 UniProt Q7KZF4 Q78PY7 RefSeq (mRNA) NM_014390 NM_019776 RefSeq (protein) NP_055205 NP_062750 Location (UCSC) Chr 7: 127.65 – 128.09 Mb Chr 6: 28.48 – 28.94 Mb PubMed search [3] [4]
Wikidata
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Clinical significance

SND1 acts as oncogene in many cancers^[14][15][16] and in hepatocellular carcinoma progression.^[10][11] SND1 promotes tumor angiogenesis in human hepatocellular carcinoma through a novel pathway which involves NF-kappaB and miR-221.^[17] SND1 promotes migration and invasion via angiotensin II type 1 receptor and TGFβ signaling.^[18] SND1 expression is regulated by Mir-184 in gliomas.^[19]

Interactions

SND1 has been shown to interact with MYB,^[20]

• PIM1,^[21] POLR2A,^[22] RBPJ,^[23][24] and STAT6.^[22]

SND1 also interacts with G3BP (stress granule protein)^[25] and AEG-1.^[10][11]