RFC3

Replication factor C subunit 3 is a protein that in humans is encoded by the RFC3 gene.^[5][6]

RFC3
Identifiers
Aliases	RFC3, RFC38, replication factor C subunit 3
External IDs	OMIM: 600405; MGI: 1916513; HomoloGene: 2188; GeneCards: RFC3; OMA:RFC3 - orthologs
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q13.2 Start 33,818,069 bp[1] End 33,966,558 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 G3 Start 151,566,221 bp[2] End 151,574,707 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad ventricular zone embryo ganglionic eminence secondary oocyte testicle right adrenal cortex left adrenal gland left adrenal cortex appendix Top expressed in medial ganglionic eminence abdominal wall maxillary prominence mandibular prominence embryo embryo epiblast ventricular zone otic placode endocardial cushion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function single-stranded DNA helicase activity ATPase activity protein binding DNA binding DNA clamp loader activity Cellular component Ctf18 RFC-like complex nucleoplasm DNA replication factor C complex nucleus Biological process nucleotide-excision repair, DNA gap filling DNA synthesis involved in DNA repair error-free translesion synthesis DNA strand elongation involved in DNA replication error-prone translesion synthesis positive regulation of DNA-directed DNA polymerase activity response to organophosphorus translesion synthesis transcription-coupled nucleotide-excision repair nucleotide-excision repair, DNA incision DNA replication nucleotide-excision repair, DNA incision, 5'-to lesion telomere maintenance via semi-conservative replication DNA-dependent DNA replication regulation of signal transduction by p53 class mediator Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5983 69263 Ensembl ENSG00000133119 ENSMUSG00000033970 UniProt P40938 Q8R323 RefSeq (mRNA) NM_002915 NM_181558 NM_027009 RefSeq (protein) NP_002906 NP_853536 NP_081285 Location (UCSC) Chr 13: 33.82 – 33.97 Mb Chr 5: 151.57 – 151.57 Mb PubMed search [3] [4]
Wikidata
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Function

The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kDa. This gene encodes the 38 kDa subunit. This subunit is essential for the interaction between the 140 kDa subunit and the core complex that consists of the 36, 37, and 40 kDa subunits. Alternatively spliced transcript variants encoding distinct isoforms have been described.^[6]

Interactions

RFC3 has been shown to interact with:

• BRD4,^[7]
• CHTF18,^[8][9]
• PCNA,^[9][10]
• RFC1,^[11][12][13] and
• RFC4.^[11][12]