RGS20

Regulator of G-protein signaling 20 is a protein that in humans is encoded by the RGS20 gene.^[5][6][7]

RGS20
Identifiers
Aliases	RGS20, RGSZ1, ZGAP1, g(z)GAP, gz-GAP, regulator of G-protein signaling 20, regulator of G protein signaling 20
External IDs	OMIM: 607193; MGI: 1929866; HomoloGene: 2745; GeneCards: RGS20; OMA:RGS20 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q11.23 Start 53,851,795 bp[1] End 53,959,303 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 A1 Start 4,979,799 bp[2] End 5,140,508 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in caudate nucleus nucleus accumbens putamen ventricular zone amygdala ganglionic eminence cingulate gyrus anterior cingulate cortex right frontal lobe Brodmann area 9 Top expressed in supraoptic nucleus substantia nigra olfactory tubercle neural layer of retina ventricular zone nucleus accumbens globus pallidus lateral septal nucleus piriform cortex primary motor cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding GTPase activator activity GTPase activity Cellular component trans-Golgi network nucleus cytoplasm membrane plasma membrane cytoplasmic vesicle Biological process negative regulation of signal transduction regulation of G protein-coupled receptor signaling pathway positive regulation of GTPase activity G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8601 58175 Ensembl ENSG00000147509 ENSMUSG00000002459 UniProt O76081 Q9QZB1 RefSeq (mRNA) NM_001286673 NM_001286674 NM_001286675 NM_003702 NM_170587 NM_001177795 NM_001290372 NM_021374 RefSeq (protein) NP_001273602 NP_001273603 NP_001273604 NP_003693 NP_733466 NP_001171266 NP_001277301 NP_067349 Location (UCSC) Chr 8: 53.85 – 53.96 Mb Chr 1: 4.98 – 5.14 Mb PubMed search [3] [4]
Wikidata
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Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins are GTPase-activating proteins for Gi (see GNAI1; MIM 139310) and Gq (see GNAQ; MIM 600998) class G-alpha proteins. They accelerate transit through the cycle of GTP binding and hydrolysis and thereby accelerate signaling kinetics and termination.[supplied by OMIM]^[7]

In melanocytic cells RGS20 gene expression may be regulated by MITF.^[8]

Interactions

RGS20 has been shown to interact with GNAO1^[9] and GNAZ.^[5][10]