RU-24969

RU-24,969 is a serotonin receptor modulator of the tetrahydropyridinylindole group related to 5-MeO-DMT which is used in scientific research.^[1][2][3]

RU-24969

Clinical data
Other names	RU-24969; RU24969
Drug class	Serotonin 5-HT1B and 5-HTA receptor agonist
Identifiers
IUPAC name 5-Methoxy-3-(1,2,5,6-tetrahydro-4-pyridinyl)-1H-indole
CAS Number	107008-28-6 Y
PubChem CID	108029
IUPHAR/BPS	23
ChemSpider	97138 Y
UNII	RKG24J8KJR
CompTox Dashboard (EPA)	DTXSID40276045
Chemical and physical data
Formula	C14H16N2O
Molar mass	228.295 g·mol−1
3D model (JSmol)	Interactive image
SMILES c3cc(OC)cc1c3[nH]cc1C=2CCNCC=2
InChI InChI=1S/C14H16N2O/c1-17-11-2-3-14-12(8-11)13(9-16-14)10-4-6-15-7-5-10/h2-4,8-9,15-16H,5-7H2,1H3 N Key:KRVMLPUDAOWOGN-UHFFFAOYSA-N N
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It is a selective agonist of the serotonin 5-HT_1A and 5-HT_1B receptors, with 5-fold preference for the latter receptor over the former.^[1][2] In studies, its affinities (K_i) were 2 nM for the serotonin 5-HT₁ receptor, 5 nM for the serotonin 5-HT_1A receptor, 4 nM for the serotonin 5-HT_1B receptor, 780 to 1,000 nM for the serotonin 5-HT₂ receptor, and 400 nM for the serotonin 5-HT_2C receptor.^[4] It also has affinity for the serotonin 5-HT_5A, 5-HT_5B, and 5-HT₇ receptors.^[5]

The drug produces MDMA-like locomotor hyperactivity in animals and this is thought to be mediated by activation of both serotonin 5-HT_1A and 5-HT_1B receptors.^{[6][1][7][8][9]} As with other serotonin 5-HT_1B receptor agonists such as CP-94,253, RU-24,969 has also been found to increase the reinforcing properties of cocaine in animals, suggesting a role for serotonin 5-HT_1B receptors in cocaine addiction as well.^[10]

RU-24,969 was first described in the scientific literature by 1980.^[11]

See also

• Tetrahydropyridinylindole
• EMD-386088
• RS134-49
• RU-28253
• RU-28306
• SN-22