SH3BGRL3

SH3 domain-binding glutamic acid-rich-like protein 3 is a protein that in humans is encoded by the SH3BGRL3 gene.^[5]

SH3BGRL3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1SJ6
Identifiers
Aliases	SH3BGRL3, HEL-S-297, SH3BP-1, TIP-B1, SH3 domain binding glutamate rich protein like 3
External IDs	OMIM: 615679; MGI: 1920973; HomoloGene: 41824; GeneCards: SH3BGRL3; OMA:SH3BGRL3 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.11 Start 26,280,086 bp[1] End 26,281,522 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D2.3 Start 133,854,717 bp[2] End 133,856,100 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte monocyte mucosa of transverse colon right lung Descending thoracic aorta ascending aorta rectum skin of abdomen spleen upper lobe of left lung Top expressed in granulocyte mesenteric lymph nodes seminal vesicula thymus zygote tibiofemoral joint spleen epithelium of stomach lip stroma of bone marrow More reference expression data BioGPS More reference expression data
Gene ontology Molecular function electron transfer activity protein-disulfide reductase activity Cellular component nucleus extracellular exosome cytoplasm nuclear body Biological process cell redox homeostasis electron transport chain Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 83442 73723 Ensembl ENSG00000142669 ENSMUSG00000028843 UniProt Q9H299 Q91VW3 RefSeq (mRNA) NM_031286 NM_080559 RefSeq (protein) NP_112576 NP_542126 Location (UCSC) Chr 1: 26.28 – 26.28 Mb Chr 4: 133.85 – 133.86 Mb PubMed search [3] [4]
Wikidata
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The 10.5kDa protein SH3 binding glutamic acid-rich protein-like 3 has an isoelectric point of 5.0. SH3 binding glutamic acid-rich (SH3BGR) gene is located to human chromosome 21. Two homologous genes, SH3BGRL and SH3BGRL3 are located to chromosome Xq13.3 and 1p34.3-35, respectively and code for small proteins similar to the N-terminal region of the SH3BGR protein.^[6] SH3BGRL3 protein shows a significant similarity to glutaredoxin 1 of E. coli, and all the three proteins are predicted to belong to thioredoxin-like protein family. Glutaredoxins (GRXs) are ubiquitous oxidoreductases, which catalyze the reduction of many intra-cellular protein disulfides and play an important role in many redox pathways. However, the SH3BGRL3 protein lacks the enzymatic function of glutaredoxins and may have a role as a regulator of redox activity.^[7]

Role in cancer

Proteins such as glutaredoxin and thioredoxin are reported as up-regulated in many cancers such as lung and pancreatic; they have been implicated in increased resistance of cancer cells to free-radicals. There is little current evidence which directly links SH3GRPL3 with survival in cancer cells, however the protein has recently been identified as up-regulated in glioblastoma multiforme compared to normal cerebral tissue on proteomic analysis.^[8] Studies of acute promyelocytic leukemia cell line NB4 have also reported up-regulation of the protein. Conversely, the related protein SH3BGRL is reported to be downregulated in fibroblasts, lymphoid cells, and splenic tumor cells transformed by the viral oncogene v-Rel.^[9] Co-expression of SH3BGRL with v-Rel in primary splenic lymphocytes reduced the number of colonies formed by 76%. Xu et al. reported SH3BGRPL3 protein as a post-translational modification of the 27kDa tumor necrosis factor alpha (TNF-α) inhibitory protein, TIP-B1. This protein is potentially involved in resistance of cells to the apoptosis-inducing effect of TNF-α.^[10]