SH3GL2

Endophilin-A1 is a protein that in humans is encoded by the SH3GL2 gene.^[5][6]

SH3GL2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1X03, 1X04, 2D4C, 2DBM
Identifiers
Aliases	SH3GL2, CNSA2, EEN-B1, SH3D2A, SH3P4, SH3 domain containing GRB2 like 2, endophilin A1
External IDs	OMIM: 604465; MGI: 700009; HomoloGene: 20652; GeneCards: SH3GL2; OMA:SH3GL2 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9p22.2 Start 17,579,066 bp[1] End 17,797,124 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 C4|4 40.23 cM Start 85,123,363 bp[2] End 85,557,432 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 23 middle temporal gyrus endothelial cell cerebellar cortex cerebellar hemisphere right hemisphere of cerebellum cerebellar vermis primary visual cortex lateral nuclear group of thalamus orbitofrontal cortex Top expressed in transitional epithelium of urinary bladder lobe of cerebellum cerebellar vermis pontine nuclei subiculum habenula deep cerebellar nuclei medial vestibular nucleus motor neuron medial dorsal nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding lipid binding identical protein binding protein homodimerization activity protein C-terminus binding protein kinase binding Cellular component cytoplasm clathrin-coated endocytic vesicle membrane membrane Golgi membrane plasma membrane synapse early endosome endosome cytosol soma perinuclear region of cytoplasm basal dendrite presynapse synaptic vesicle membrane photoreceptor ribbon synapse Schaffer collateral - CA1 synapse hippocampal mossy fiber to CA3 synapse glutamatergic synapse presynaptic cytosol Biological process negative regulation of epidermal growth factor receptor signaling pathway endocytosis antigen processing and presentation of exogenous peptide antigen via MHC class II central nervous system development synaptic vesicle endocytosis regulation of receptor internalization signal transduction membrane organization synaptic vesicle uncoating neuron projection development dendrite extension cellular response to brain-derived neurotrophic factor stimulus lipid tube assembly membrane tubulation membrane bending vesicle scission positive regulation of membrane tubulation regulation of clathrin-dependent endocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6456 20404 Ensembl ENSG00000107295 ENSMUSG00000028488 UniProt Q99962 Q62420 RefSeq (mRNA) NM_003026 NM_019535 RefSeq (protein) NP_003017 NP_062408 Location (UCSC) Chr 9: 17.58 – 17.8 Mb Chr 4: 85.12 – 85.56 Mb PubMed search [3] [4]
Wikidata
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Interactions

SH3GL2 has been shown to interact with DNM1,^[7][8] Amphiphysin,^[7][8] ADAM9,^[9] SH3KBP1^[10] and ADAM15.^[9]