Structure specific recognition protein 1

FACT complex subunit SSRP1 also known as structure specific recognition protein 1 is a protein that in humans is encoded by the SSRP1 gene.^[5]

SSRP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4IFS
Identifiers
Aliases	SSRP1, FACT, FACT80, T160, Structure specific recognition protein 1
External IDs	OMIM: 604328; MGI: 107912; HomoloGene: 110735; GeneCards: SSRP1; OMA:SSRP1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q12.1 Start 57,325,986 bp[1] End 57,335,892 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 D|2 49.45 cM Start 84,867,578 bp[2] End 84,877,453 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence tendon of biceps brachii gastrocnemius muscle Achilles tendon islet of Langerhans body of pancreas left ovary body of uterus mucosa of transverse colon Top expressed in otic placode saccule otic vesicle tail of embryo mandibular prominence abdominal wall genital tubercle maxillary prominence primitive streak somite More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding chromatin binding protein binding RNA binding DNA-binding transcription factor activity, RNA polymerase II-specific nucleosome binding histone binding Cellular component nucleolus nucleoplasm chromosome nucleus FACT complex Biological process DNA replication transcription elongation from RNA polymerase II promoter regulation of transcription, DNA-templated transcription by RNA polymerase II DNA repair transcription, DNA-templated cellular response to DNA damage stimulus regulation of signal transduction by p53 class mediator regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6749 20833 Ensembl ENSG00000149136 ENSMUSG00000027067 UniProt Q08945 Q08943 RefSeq (mRNA) NM_003146 NM_001136081 NM_182990 RefSeq (protein) NP_003137 NP_001129553 NP_892035 Location (UCSC) Chr 11: 57.33 – 57.34 Mb Chr 2: 84.87 – 84.88 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63.^[5]

Interactions

Structure specific recognition protein 1 has been shown to interact with NEK9.^[6] SSRP1 further interacts with transcriptional activator p63.^[7] SSRP1 enhances the activity of full-length p63, but it has no effect on the N-terminus-deleted p63 (DeltaN-p63) variant.