TH1L

Negative elongation factor C/D is a protein that in humans is encoded by the TH1L gene.^[5][6][7]

NELFCD
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5L3X
Identifiers
Aliases	NELFCD, NELF-C, NELF-D, TH1, TH1L, HSPC130, negative elongation factor complex member C/D
External IDs	OMIM: 605297; MGI: 1926424; HomoloGene: 9496; GeneCards: NELFCD; OMA:NELFCD - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.32 Start 58,981,208 bp[1] End 58,995,133 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H4 Start 174,257,597 bp[2] End 174,269,295 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in anterior pituitary ventricular zone ganglionic eminence right lobe of thyroid gland left lobe of thyroid gland left ovary right hemisphere of cerebellum right ovary islet of Langerhans right uterine tube Top expressed in yolk sac ventricular zone otic vesicle superior cervical ganglion neural layer of retina genital tubercle epiblast otic placode saccule tail of embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding RNA binding Cellular component membrane NELF complex nucleus nucleoplasm Biological process transcription elongation from RNA polymerase II promoter positive regulation of viral transcription negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated transcription by RNA polymerase II transcription, DNA-templated negative regulation of transcription elongation from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51497 57314 Ensembl ENSG00000101158 ENSMUSG00000016253 UniProt Q8IXH7 Q922L6 RefSeq (mRNA) NM_016397 NM_198976 NM_020580 RefSeq (protein) NP_945327 NP_065605 Location (UCSC) Chr 20: 58.98 – 59 Mb Chr 2: 174.26 – 174.27 Mb PubMed search [3] [4]
Wikidata
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Function

The NELF^{[clarification needed]} complex of proteins interacts with the DSIF^{[clarification needed]} protein complex to repress transcriptional elongation by RNA polymerase II. The protein encoded by this gene is an essential part of the NELF complex. Alternative translation initiation site usage results in the formation of two isoforms with different N-termini.^[7]

Interactions

TH1L has been shown to interact with:

• ARAF,^[8][9]
• Cofactor of BRCA1,^[10][11] and
• RDBP.^[10][11]