Cofactor of BRCA1

Cofactor of BRCA1, also known as COBRA1, is a human gene^[5] that encodes NELF-B.

NELFB
Identifiers
Aliases	NELFB, COBRA1, NELF-B, Cofactor of BRCA1, negative elongation factor complex member B
External IDs	OMIM: 611180; MGI: 1931035; HomoloGene: 121600; GeneCards: NELFB; OMA:NELFB - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q34.3 Start 137,255,327 bp[1] End 137,273,542 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 A3 Start 25,089,724 bp[2] End 25,101,501 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart ventricular zone right frontal lobe mucosa of transverse colon cingulate gyrus anterior cingulate cortex ganglionic eminence Amygdala tendon of biceps brachii stromal cell of endometrium Top expressed in otic vesicle saccule medullary collecting duct mesenteric lymph nodes molar otic placode granulocyte dentate gyrus of hippocampal formation granule cell left lung lobe neural layer of retina More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding RNA binding Cellular component nucleus cytoplasm NELF complex nucleoplasm Biological process transcription elongation from RNA polymerase II promoter regulation of transcription, DNA-templated transcription by RNA polymerase II negative regulation of transcription elongation from RNA polymerase II promoter transcription, DNA-templated negative regulation of transcription, DNA-templated cell population proliferation stem cell differentiation negative regulation of stem cell differentiation positive regulation of viral transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 25920 58202 Ensembl ENSG00000188986 ENSMUSG00000013465 UniProt Q8WX92 Q8C4Y3 RefSeq (mRNA) NM_015456 NM_021393 NM_001310157 RefSeq (protein) NP_056271 NP_001297086 NP_067368 Location (UCSC) Chr 9: 137.26 – 137.27 Mb Chr 2: 25.09 – 25.1 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

NELF-B is a subunit of negative elongation factor (NELF), which also includes NELF-A (WHSC2; MIM 606026), either NELF-C or NELF-D (TH1L; MIM 605297), and NELF-E (RDBP; MIM 154040). NELF acts with DRB sensitivity-inducing factor (DSIF), a heterodimer of SPT4 (SUPT4H1; MIM 603555) and SPT5 (SUPT5H; MIM 602102), to cause transcriptional pausing of RNA polymerase II (see MIM 180660).^[6] COBRA1 was initially identified in a yeast two-hybrid screen using the BRCT1 domain of BRCA1 as bait.^[7]

Interactions

Cofactor of BRCA1 has been shown to interact with:

• BRCA1^[8]
• C-Fos,^[9]
• C-jun,^[9]
• Estrogen receptor alpha,^[10]
• RDBP,^[11][12] and
• TH1L.^[11][13]