TUBB

For persons named Tubb, see Tubb.

Tubulin beta chain is a protein that in humans is encoded by the TUBB gene.^[5][6][7]

TUBB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3QNZ, 3QO0
Identifiers
Aliases	TUBB, CDCBM6, M40, OK/SW-cl.56, TUBB1, TUBB5, CSCSC1, tubulin beta class I
External IDs	OMIM: 191130; MGI: 107812; HomoloGene: 69099; GeneCards: TUBB; OMA:TUBB - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.33 Start 30,717,435 bp[1] End 30,725,538 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 B1 Start 36,144,813 bp[2] End 36,149,198 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone smooth muscle tissue stromal cell of endometrium appendix ovary left ovary islet of Langerhans placenta right ovary Top expressed in medial ganglionic eminence saccule otic placode otic vesicle tail of embryo maxillary prominence primitive streak somite mandibular prominence hand More reference expression data BioGPS n/a
Gene ontology Molecular function GTPase activating protein binding nucleotide binding protein domain specific binding protein-containing complex binding GTP binding structural molecule activity structural constituent of cytoskeleton protein binding GTPase activity MHC class I protein binding ubiquitin protein ligase binding Cellular component cell body extracellular region nuclear envelope lumen cytoplasmic ribonucleoprotein granule extracellular exosome extracellular matrix microtubule cytoskeleton nucleus microtubule cytoskeleton azurophil granule lumen cytoplasm membrane raft protein-containing complex Biological process cytoskeleton-dependent intracellular transport spindle assembly cell division G2/M transition of mitotic cell cycle cellular process or phenomenon natural killer cell mediated cytotoxicity microtubule-based process neutrophil degranulation ciliary basal body-plasma membrane docking regulation of G2/M transition of mitotic cell cycle microtubule cytoskeleton organization mitotic cell cycle regulation of synapse organization cytoskeleton organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 203068 22154 Ensembl ENSG00000196230 ENSG00000232421 ENSG00000183311 ENSG00000224156 ENSG00000235067 ENSG00000232575 ENSG00000227739 ENSG00000229684 ENSMUSG00000001525 UniProt P07437 Q5SU16 P99024 RefSeq (mRNA) NM_001293212 NM_001293213 NM_001293214 NM_001293215 NM_001293216 NM_178014 NM_011655 RefSeq (protein) NP_001280141 NP_001280142 NP_001280143 NP_001280144 NP_001280145 NP_821133 NP_821133.1 NP_035785 Location (UCSC) Chr 6: 30.72 – 30.73 Mb Chr 17: 36.14 – 36.15 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

TUBB has been shown to interact with NCOA6^[8] and SYT9.^[9]

See also

• Tubulin