Vesicle-associated membrane protein

Vesicle associated membrane proteins (VAMPs) are a family of SNARE proteins with similar structure, and are mostly involved in vesicle fusion.

• VAMP1 and VAMP2 proteins known as synaptobrevins are expressed in brain and are constituents of the synaptic vesicles, where they participate in neurotransmitter release.
• VAMP3 (known as cellubrevin) is ubiquitously expressed and participates in regulated and constitutive exocytosis as a constituent of secretory granules and secretory vesicles.
• VAMP5 and VAMP7 participate in constitutive exocytosis.
  • VAMP5 is a constituent of secretory vesicles, myotubes and tubulovesicular structures.
  • VAMP7 is found both in secretory granules and endosomes.
• VAMP8 (known as endobrevin) participates in endocytosis and is found in early endosomes. VAMP8 also participates the regulated exocytosis in pancreatic acinar cells.
• VAMP4 is involved in transport from the Golgi.^[1]

Synaptobrevin
Three different views of the high resolution structure of a truncated neuronal SNARE complex. Legend: synaptobrevin-2 (red), Syntaxin-1 (pink), SNAP-25 (purple).
Identifiers
Symbol	Synaptobrevin
Pfam	PF00957
InterPro	IPR016444
PROSITE	PDOC00368
SCOP2	1sfc / SCOPe / SUPFAM
OPM superfamily	197
OPM protein	4wy4
Membranome	198
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Hypothetic models of VAMP2 conformations and engagement in SNARE complex assembly for neurotransmitter release