Discoidin domain

Discoidin domain (also known as F5/8 type C domain, or C2-like domain) is major protein domain of many blood coagulation factors.

F5/8 type C domain
Structure of the membrane-binding C2 domain of factor VIII.[1]
Identifiers
Symbol	F5_F8_type_C
Pfam	PF00754
InterPro	IPR000421
PROSITE	PDOC00988
SCOP2	1fac / SCOPe / SUPFAM
OPM superfamily	46
OPM protein	1sdd
CDD	cd00057
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Blood coagulation factors V and VIII contain a C-terminal, twice repeated, domain of about 150 amino acids, which is often called "C2-like domain" (that is unrelated to the C2 domain). In the Dictyostelium discoideum (Slime mold) cell adhesion protein discoidin, a related domain, named discoidin I-like domain, DLD, or DS, has been found which shares a common C-terminal region of about 110 amino acids with the FA58C domain, but whose N-terminal 40 amino acids are much less conserved. Similar domains have been detected in other extracellular and membrane proteins.^[2][3][4] In coagulation factors V and VIII the repeated domains compose part of a larger functional domain which promotes binding to anionic phospholipids on the surface of platelets and endothelial cells.^[5] The C-terminal domain of the second FA58C repeat (C2) of coagulation factor VIII has been shown to be responsible for phosphatidylserine-binding and essential for activity.^[6][7] FA58C contains two conserved cysteines in most proteins, which link the extremities of the domain by a disulfide bond.^[8][9][10] A further disulfide bond is located near the C-terminal of the second FA58C domain in MFGM Q08431.^[10]

Human proteins containing this domain

AEBP1; BTBD9; CASPR4; CNTNAP1; CNTNAP2; CNTNAP3; CNTNAP4; CNTNAP5; CPXM1; CPXM2; DCBLD1; DCBLD2; DDR1; DDR2; EDIL3; F5; F8; F8B; MFGE8; NRP1; NRP2; RS1; SSPO; UNC13A