CAND1

Cullin-associated NEDD8-dissociated protein 1 is a protein that in humans is encoded by the CAND1 gene.^[5][6][7]

CAND1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1U6G, 4A0C
Identifiers
Aliases	CAND1, TIP120, TIP120A, cullin associated and neddylation dissociated 1
External IDs	OMIM: 607727; MGI: 1261820; HomoloGene: 10202; GeneCards: CAND1; OMA:CAND1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q14.3-q15 Start 67,269,358 bp[1] End 67,319,953 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 D2|10 67.08 cM Start 119,035,160 bp[2] End 119,075,960 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence stromal cell of endometrium Achilles tendon islet of Langerhans endothelial cell appendix left ovary right ovary parietal pleura Top expressed in spermatocyte spermatid tail of embryo somite mandibular prominence maxillary prominence Gonadal ridge epiblast cumulus cell morula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function TBP-class protein binding protein binding Cellular component cytoplasm cullin-RING ubiquitin ligase complex Golgi apparatus extracellular exosome membrane nucleus ubiquitin ligase complex extracellular region secretory granule lumen ficolin-1-rich granule lumen nucleoplasm cytosol Biological process positive regulation of transcription, DNA-templated SCF complex assembly cell differentiation positive regulation of RNA polymerase II transcription preinitiation complex assembly negative regulation of catalytic activity protein ubiquitination neutrophil degranulation cellular iron ion homeostasis post-translational protein modification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55832 71902 Ensembl ENSG00000111530 ENSMUSG00000020114 UniProt Q86VP6 Q6ZQ38 RefSeq (mRNA) NM_001329674 NM_001329675 NM_001329676 NM_018448 NM_027994 RefSeq (protein) NP_001316603 NP_001316604 NP_001316605 NP_060918 NP_082270 Location (UCSC) Chr 12: 67.27 – 67.32 Mb Chr 10: 119.04 – 119.08 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

CAND1 has been shown to interact with:

• CUL1,^[8][9]
• CUL2,^[8][9]
• CUL3,^[8]
• CUL4A,^[8]
• CUL4B,^[8]
• DCUN1D1,^[10] and
• RBX1.^[8][10]