DCUN1D1

DCN1-like protein 1 is a protein that in humans is encoded by the DCUN1D1 gene.^[5][6][7]

DCUN1D1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3TDU, 3TDZ, 4P5O
Identifiers
Aliases	DCUN1D1, DCNL1, DCUN1L1, RP42, SCCRO, SCRO, Tes3, defective in cullin neddylation 1 domain containing 1
External IDs	OMIM: 605905; MGI: 2150386; HomoloGene: 10773; GeneCards: DCUN1D1; OMA:DCUN1D1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q26.33 Start 182,938,074 bp[1] End 182,985,953 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 B Start 35,946,254 bp[2] End 35,991,594 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis sperm endothelial cell tendon of biceps brachii trabecular bone buccal mucosa cell Achilles tendon tail of epididymis middle temporal gyrus Top expressed in zygote spermatid Rostral migratory stream secondary oocyte genital tubercle spermatocyte interventricular septum Paneth cell triceps brachii muscle vastus lateralis muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cullin family protein binding ubiquitin-like protein binding protein binding ubiquitin conjugating enzyme binding Cellular component ubiquitin ligase complex nucleus cytosol Biological process protein neddylation positive regulation of ubiquitin-protein transferase activity post-translational protein modification positive regulation of protein neddylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54165 114893 Ensembl ENSG00000043093 ENSMUSG00000027708 UniProt Q96GG9 Q9QZ73 RefSeq (mRNA) NM_001308101 NM_020640 NM_001205361 NM_001205362 NM_033623 RefSeq (protein) NP_001295030 NP_065691 NP_001192290 NP_001192291 NP_296372 Location (UCSC) Chr 3: 182.94 – 182.99 Mb Chr 3: 35.95 – 35.99 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

DCUN1D1 is amplified in several cancer types, including squamous cell cancers, and may act as an oncogenic driver in cancer cells.^[8][9][10]

Interactions

DCUN1D1 has been shown to interact with:

• CAND1,^[11]
• CUL1,^[11]
• CUL2,^[11]
• CUL3^[11] and
• RBX1.^[11]