CDC6

Cell division control protein 6 homolog is a protein that in humans is encoded by the CDC6 gene.^[5][6]

CDC6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CCH, 2CCI, 4I5L, 4I5N
Identifiers
Aliases	CDC6, CDC18L, HsCDC18, Hscell division cycle 6, MGORS5
External IDs	OMIM: 602627; MGI: 1345150; HomoloGene: 68172; GeneCards: CDC6; OMA:CDC6 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.2 Start 40,287,879 bp[1] End 40,304,657 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 D Start 98,798,627 bp[2] End 98,814,766 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence secondary oocyte testicle rectum stromal cell of endometrium mucosa of transverse colon bone marrow cells appendix gonad Top expressed in fetal liver hematopoietic progenitor cell primitive streak epiblast abdominal wall morula primary oocyte morula otic placode endocardial cushion mandibular prominence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding kinase binding protein binding ATP binding DNA replication origin binding Cellular component spindle pole spindle midzone nucleus cytoplasm nucleolus nucleoplasm cytosol Biological process regulation of cyclin-dependent protein serine/threonine kinase activity cellular response to vasopressin positive regulation of fibroblast proliferation negative regulation of DNA replication regulation of transcription involved in G1/S transition of mitotic cell cycle cell division positive regulation of cytokinesis DNA replication checkpoint signaling DNA replication cellular response to angiotensin DNA replication initiation traversing start control point of mitotic cell cycle positive regulation of chromosome segregation positive regulation of cyclin-dependent protein serine/threonine kinase activity regulation of mitotic metaphase/anaphase transition cell cycle negative regulation of cell population proliferation mitotic cell cycle G1/S transition of mitotic cell cycle mitotic DNA replication checkpoint signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 990 23834 Ensembl ENSG00000094804 ENSMUSG00000017499 UniProt Q99741 O89033 RefSeq (mRNA) NM_001254 NM_001025779 NM_011799 NM_001362735 RefSeq (protein) NP_001245 NP_001020950 NP_035929 NP_001349664 Location (UCSC) Chr 17: 40.29 – 40.3 Mb Chr 11: 98.8 – 98.81 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in the cell nucleus during cell cycle phase G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during the cell cycle is regulated through its phosphorylation by cyclin-dependent kinases. Transcription of this protein was reported to be regulated in response to mitogenic signals through a transcriptional control mechanism involving E2F proteins.^[7]

Interactions

CDC6 has been shown to interact with ORC1L,^[6][8] ORC2L,^[8][9] Cyclin A2,^[6][10] PPP2R3B,^[11] MCM3,^[9][12] PPP2R3A,^[13] MCM7^[8][12] and PSKH1.^[10]

See also

• Cdc6, the family of orthologs in eukaryotes