GAS5

Growth arrest-specific 5 is a non-protein coding RNA that in humans is encoded by the GAS5 gene.^[3][4]

GAS5
Identifiers
Aliases	GAS5, NCRNA00030, SNHG2, growth arrest specific 5 (non-protein coding)
External IDs	OMIM: 608280; GeneCards: GAS5; OMA:GAS5 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q25.1 Start 173,863,900 bp[1] End 173,868,882 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left ovary body of pancreas right ovary cartilage tissue right uterine tube canal of the cervix skin of abdomen ganglionic eminence skin of arm body of uterus n/a More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 60674 n/a Ensembl ENSG00000234741 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 1: 173.86 – 173.87 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

GAS5 noncoding RNA, which accumulates in growth arrested cells, acts as a decoy hormone response element for the glucocorticoid receptor (GR) and hence blocks the upregulation of gene expression by activated GR.^[5][6]

A number of studies have linked GAS5 to apoptosis and it may play a role in the progression of some types of cancer.^[7][8][9]

The GAS5 introns host several snoRNA sequences, including SNORD81, SNORD47, SNORD80, SNORD79, SNORD78, SNORD44, SNORD77, SNORD76, SNORD75 and SNORD74.^{[4][10][11][12]} These intronic sequences are more conserved than the exons of the host gene, these sorts of genes are often called "inside-out genes".^[13]

It was recently discovered that the nonsense-mediated degradation pathway can regulate the function of the GAS5 in mammalian cells.^[14]