GRIN2D

Glutamate [NMDA] receptor subunit epsilon-4 is a protein that in humans is encoded by the GRIN2D gene.^[5][6][7]

GRIN2D
Identifiers
Aliases	GRIN2D, EB11, GluN2D, NMDAR2D, NR2D, glutamate ionotropic receptor NMDA type subunit 2D, EIEE46, DEE46
External IDs	OMIM: 602717; MGI: 95823; HomoloGene: 648; GeneCards: GRIN2D; OMA:GRIN2D - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.33 Start 48,393,668 bp[1] End 48,444,931 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 B3|7 29.54 cM Start 45,831,883 bp[2] End 45,878,378 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cingulate gyrus anterior cingulate cortex prefrontal cortex ganglionic eminence Hypothalamus ventricular zone right frontal lobe lateral nuclear group of thalamus Amygdala dorsolateral prefrontal cortex Top expressed in molecular layer of cerebellar cortex lumbar subsegment of spinal cord molar primary visual cortex seminiferous tubule dorsomedial hypothalamic nucleus superior frontal gyrus spermatocyte dentate gyrus of hippocampal formation granule cell neural layer of retina More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ion channel activity protein binding extracellularly glutamate-gated ion channel activity ionotropic glutamate receptor activity NMDA glutamate receptor activity glutamate-gated calcium ion channel activity signaling receptor activity Cellular component integral component of membrane postsynaptic membrane membrane plasma membrane synapse cell junction intracellular anatomical structure integral component of plasma membrane NMDA selective glutamate receptor complex postsynaptic density membrane Biological process startle response regulation of sensory perception of pain adult locomotory behavior ion transport MAPK cascade ionotropic glutamate receptor signaling pathway excitatory postsynaptic potential calcium-mediated signaling calcium ion transmembrane import into cytosol regulation of molecular function brain development regulation of synaptic plasticity long-term potentiation excitatory chemical synaptic transmission Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2906 14814 Ensembl ENSG00000105464 ENSMUSG00000002771 UniProt O15399 Q03391 RefSeq (mRNA) NM_000836 NM_008172 RefSeq (protein) NP_000827 NP_032198 Location (UCSC) Chr 19: 48.39 – 48.44 Mb Chr 7: 45.83 – 45.88 Mb PubMed search [3] [4]
Wikidata
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Function

N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D).^[7]

Interactions

GRIN2D has been shown to interact with Interleukin 16.^[8]

See also

• Glutamate receptor
• NMDA receptor