GRIN2C

Glutamate [NMDA] receptor subunit epsilon-3 is a protein that in humans is encoded by the GRIN2C gene.^[5][6]

GRIN2C
Identifiers
Aliases	GRIN2C, GluN2C, NMDAR2C, NR2C, glutamate ionotropic receptor NMDA type subunit 2C
External IDs	OMIM: 138254; MGI: 95822; HomoloGene: 647; GeneCards: GRIN2C; OMA:GRIN2C - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q25.1 Start 74,842,023 bp[1] End 74,861,504 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 E2|11 80.8 cM Start 115,139,995 bp[2] End 115,158,069 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum paraflocculus of cerebellum cerebellar vermis parotid gland right auricle of heart putamen right lobe of thyroid gland amygdala caudate nucleus right frontal lobe Top expressed in lobe of cerebellum cerebellar vermis entorhinal cortex perirhinal cortex CA3 field medial dorsal nucleus visual cortex granular layer choroid plexus of fourth ventricle lateral geniculate nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ion channel activity protein binding ionotropic glutamate receptor activity cation channel activity extracellularly glutamate-gated ion channel activity NMDA glutamate receptor activity glutamate-gated calcium ion channel activity signaling receptor activity transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential Cellular component integral component of membrane postsynaptic membrane membrane postsynaptic density plasma membrane synapse cell junction intracellular anatomical structure integral component of plasma membrane NMDA selective glutamate receptor complex postsynaptic density membrane glutamatergic synapse Biological process protein localization glutamate receptor signaling pathway neuromuscular process controlling balance negative regulation of protein catabolic process regulation of membrane potential directional locomotion ion transport MAPK cascade ionotropic glutamate receptor signaling pathway response to wounding excitatory postsynaptic potential calcium-mediated signaling calcium ion transmembrane import into cytosol regulation of molecular function transport brain development regulation of synaptic plasticity long-term potentiation excitatory chemical synaptic transmission protein localization to postsynaptic membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2905 14813 Ensembl ENSG00000161509 ENSMUSG00000020734 UniProt Q14957 Q01098 RefSeq (mRNA) NM_000835 NM_001278553 NM_010350 RefSeq (protein) NP_000826 NP_001265482 NP_034480 Location (UCSC) Chr 17: 74.84 – 74.86 Mb Chr 11: 115.14 – 115.16 Mb PubMed search [3] [4]
Wikidata
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Function

N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D).^[6]

Interactions

GRIN2C has been shown to interact with DLG4^[7] and DLG3.^[7]

See also

• Glutamate receptor
• NMDA receptor