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HLA-DR1
Serotype of cell surface receptors From Wikipedia, the free encyclopedia
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HLA-DR1 (DR1) is a HLA-DR serotype that recognizes the DRB1*01 gene products. It has been observed to be common among centenarians.[2][3][4]
| ||
| DR1 binding pocket with ligand PDB: 2G9H [1] | ||
major histocompatibility complex, class II, DR1 | ||
| Haplotypes groups | DRA*01:DRB1*01:01 DRA*01:DRB1*01:02 DRA*01:DRB1*01:03 | |
| Structure (See HLA-DR) | ||
| Identifiers | alpha *01:01 | |
| Symbol(s) | HLA-DRA[permanent dead link] | |
| EBI-HLA | DRA *01:01 | |
| Identifiers | beta 1 *01:01, *01:02, *01:03 . . . | |
| Symbol(s) | HLA-DRB1[permanent dead link] | |
| Shared data | ||
| Locus | chr.6 6p21.31 | |
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Serology
| DRB1* | DR1 | DR103 | Sample | |
| allele | % | % | % | size (N) |
| *01:01 | 97% | 6317 | ||
| *01:02 | 95% | 2035 | ||
| *01:03 | 56% | 12% | 1186 | |
| *01:05 | >50% | 2 | ||
The serology for the most common DR1 alleles is excellent. The serology for alleles *01:04, *01:06, *01:09, *01:10, *0112, *0115, and *0116 is unknown.
Disease associations
Summarize
Perspective
By serotype
DR1 is associated with seronegative[6]-rheumatoid arthritis,[7][8] penicillamine-induced myasthenia,[9] and schizophrenia.[10] DR1 is increased in patients with systemic sclerosis and arthritis[11] and in ulcerative colitis with patients that have articular manifestations.[12]
By allele
DRB1*01:01 is associated with rheumatoid arthritis,[13] in anti-Jk(a) mediated hemolytic transfusion reactions,[14] foliaceous pemphigus,[15] HTLV-1-associated myelopathy/tropical spastic paraparesis, and [16] lichen planus.[17] In lyme disease arthritis, *01:01 appears to play a role in presentation of triggering microbial antigens.[18]
DRB1*01:02 is associated with rheumatoid arthritis,[13] in anti-Jk(a) mediated hemolytic transfusion reactions,[14] psoriasis vulgaris,[19] and recurrent respiratory papillomatosis[20]
DRB1*01:03 is associated with colonic Crohn's disease[21] and ulcerative colitis.[22][23]
By genotype
DRB1*01:01/*0404 and *01:01/*0401 increases risk of mortality in rheumatoid arthritis, with ischemic heart disease and smoking.[24] these same genotypes are associated with rheumatoid vasculitis.[25]
By haplotype
DRB1*01:02:DQB1*05:01 is associated with psoriasis vulgaris[19] and tubulointerstitial nephritis & uveitis syndrome,[26] but is relatively protective against juvenile diabetes.[27]
DR1-DQ5 is associated with tubulointerstitial nephritis & uveitis syndrome.[26]
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Rheumatoid arthritis
DR1 are associated with rheumatoid arthritis, and while not the strongest association with the highest risk for early onset arthritis is within the DR4-bearing Native American population.[clarification needed] There frequency of DR4-DQ8 haplotypes reach extreme nodal levels. Arthritis has been identified in a pre-Columbian remains from Italy, the affected individual bearing the DRB1*01:01 allele.[28] DRB1*01:01 and most DR4 have in common a 'shared epitope'.[29][30] In this hypothesis a common region of the beta chain, positions 67 to 74, are common and may be integral to presenting auto-immunological peptides.
Genetic linkage
HLA-DR1 is not genetically linked to DR51, DR52 or DR53, but is linked to HLA-DQ1 and DQ5 serotypes.
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References
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