LSM7

U6 snRNA-associated Sm-like protein LSm7 is a protein that in humans is encoded by the LSM7 gene.^[5][6][7]

LSM7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3JCR
Identifiers
Aliases	LSM7, YNL147W, LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated
External IDs	OMIM: 607287; MGI: 1913344; HomoloGene: 6781; GeneCards: LSM7; OMA:LSM7 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 2,321,520 bp[1] End 2,328,611 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 C1 Start 80,688,655 bp[2] End 80,691,043 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon granulocyte ganglionic eminence pituitary gland ventricular zone spleen anterior pituitary monocyte C1 segment left ovary Top expressed in embryo yolk sac embryo blastocyst morula ventricular zone dentate gyrus of hippocampal formation granule cell neural layer of retina lip thymus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding RNA binding U6 snRNA binding Cellular component cytosol catalytic step 2 spliceosome spliceosomal tri-snRNP complex U6 snRNP U12-type spliceosomal complex nucleoplasm Lsm1-7-Pat1 complex spliceosomal complex U2-type prespliceosome nucleus U4/U6 x U5 tri-snRNP complex U2-type precatalytic spliceosome Lsm2-8 complex Biological process mRNA splicing, via spliceosome RNA processing mRNA processing exonucleolytic catabolism of deadenylated mRNA RNA splicing nuclear-transcribed mRNA catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51690 66094 Ensembl ENSG00000130332 ENSMUSG00000035215 UniProt Q9UK45 Q9CQQ8 RefSeq (mRNA) NM_016199 NM_025349 NM_001359148 NM_001359149 NM_001359150 RefSeq (protein) NP_057283 NP_079625 NP_001346077 NP_001346078 NP_001346079 Location (UCSC) Chr 19: 2.32 – 2.33 Mb Chr 10: 80.69 – 80.69 Mb PubMed search [3] [4]
Wikidata
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Function

Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM]^[7]

Interactions

LSM7 has been shown to interact with TACC1^[8][9] and LSM2.^[10][11]