MST4

Serine/threonine protein kinase MST4, also known as mammalian STE20-like protein kinase 4 (MST-4), is a protein that in humans is encoded by the MST4 gene.^[5]

STK26
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3GGF, 3W8I, 4FZA, 4FZD, 4FZF, 4GEH
Identifiers
Aliases	STK26, MASK, MST4, serine/threonine protein kinase 26, serine/threonine kinase 26
External IDs	OMIM: 300547; MGI: 1917665; HomoloGene: 84402; GeneCards: STK26; OMA:STK26 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq26.2 Start 132,023,302 bp[1] End 132,075,943 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X A5 Start 49,929,924 bp[2] End 49,981,974 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in germinal epithelium tibia tail of epididymis palpebral conjunctiva seminal vesicula cartilage tissue epithelium of nasopharynx bone marrow trabecular bone amniotic fluid Top expressed in mandibular prominence abdominal wall transitional epithelium of urinary bladder efferent ductule mesenteric lymph nodes condyle endocardial cushion superior cervical ganglion atrioventricular junction parotid gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity protein kinase activity nucleotide binding protein homodimerization activity metal ion binding kinase activity protein binding identical protein binding ATP binding magnesium ion binding protein serine/threonine kinase activity MAP kinase kinase kinase kinase activity Cellular component cytoplasm cytosol Golgi apparatus Golgi membrane Golgi-associated vesicle apical plasma membrane perinuclear region of cytoplasm extracellular exosome cell periphery vesicle membrane membrane Biological process regulation of apoptotic process microvillus assembly phosphorylation regulation of hydrogen peroxide-induced cell death protein phosphorylation protein autophosphorylation response to hydrogen peroxide apoptotic process execution phase of apoptosis cellular response to starvation negative regulation of cell migration MAPK cascade regulation of mitotic cell cycle stress-activated protein kinase signaling cascade neuron projection morphogenesis signal transduction activation of protein kinase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51765 70415 Ensembl ENSG00000134602 ENSMUSG00000031112 UniProt Q9P289 Q99JT2 RefSeq (mRNA) NM_001042452 NM_001042453 NM_016542 NM_133729 NM_001313744 RefSeq (protein) NP_001035917 NP_001035918 NP_057626 NP_001300673 NP_598490 Location (UCSC) Chr X: 132.02 – 132.08 Mb Chr X: 49.93 – 49.98 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20-like kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy-terminal regulatory domain that mediates homodimerization. The protein kinase localizes to the Golgi apparatus and is specifically activated by binding to the Golgi matrix protein GM130. It is also cleaved by caspase-3 in vitro, and may function in the apoptotic pathway. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.^[5]

Interactions

RP6-213H19.1 has been shown to interact with:

• CTTNBP2NL,^[6]
• CTTNBP2,^[6]
• FAM40A,^[6]
• MOBKL3,^[6]
• PDCD10,^[6]
• STRN3,^[6] and
• STRN.^[6]