ORC4

Origin recognition complex subunit 4 is a protein that in humans is encoded by the ORC4 (ORC4L) gene.^[5][6][7]

ORC4
Identifiers
Aliases	ORC4, ORC4L, ORC4P, origin recognition complex subunit 4
External IDs	OMIM: 603056; MGI: 1347043; HomoloGene: 8059; GeneCards: ORC4; OMA:ORC4 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q23.1 Start 147,930,396 bp[1] End 148,021,604 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 C1.1 Start 48,792,836 bp[2] End 48,840,289 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon oocyte islet of Langerhans ganglionic eminence kidney tubule bronchial epithelial cell corpus callosum endothelial cell ventricular zone right uterine tube Top expressed in otic placode saccule otic vesicle spermatocyte tail of embryo ventricular zone neural layer of retina embryo epiblast superior frontal gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding DNA binding DNA replication origin binding protein binding ATP binding Cellular component nuclear origin of replication recognition complex nucleolus origin recognition complex nucleus nucleoplasm cytosol Biological process G1 phase DNA replication DNA replication initiation G1/S transition of mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5000 26428 Ensembl ENSG00000115947 ENSMUSG00000026761 UniProt O43929 O88708 RefSeq (mRNA) NM_001190879 NM_001190881 NM_001190882 NM_002552 NM_181741 NM_181742 NM_001374270 NM_001374272 NM_001177313 NM_011958 NM_001355296 RefSeq (protein) NP_001177808 NP_001177810 NP_001177811 NP_002543 NP_859525 NP_859526 NP_001361199 NP_001361201 NP_001170784 NP_036088 NP_001342225 Location (UCSC) Chr 2: 147.93 – 148.02 Mb Chr 2: 48.79 – 48.84 Mb PubMed search [3] [4]
Wikidata
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Function

The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. It has been shown to form a core complex with ORC2L, -3L, and -5L. Three alternatively spliced transcript variants encoding the same protein have been reported.^[7]

Interactions

ORC4 has been shown to interact with:

• MCM2,^[8]
• MCM3,^[8]
• MCM4,^[8]
• MCM6,^[8]
• ORC1,^[8]
• ORC2,^{[5][8][9][10]}
• ORC3,^[9][10][11]
• ORC5,^[8][9][12] and
• ORC6.^[8]