MCM4

DNA replication licensing factor MCM4 is a protein that in humans is encoded by the MCM4 gene.^[4]

MCM4
Identifiers
Aliases	MCM4, CDC21, CDC54, NKCD, NKGCD, P1-CDC21, hCdc21, minichromosome maintenance complex component 4, IMD54
External IDs	OMIM: 602638; MGI: 103199; HomoloGene: 40496; GeneCards: MCM4; OMA:MCM4 - orthologs
Gene location (Mouse) Chr. Chromosome 16 (mouse)[1] Band 16 A2|16 10.09 cM Start 15,441,761 bp[1] End 15,455,264 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence bone marrow cells human penis stromal cell of endometrium oocyte appendix trabecular bone rectum sperm skin of abdomen Top expressed in mandibular prominence maxillary prominence primitive streak somite external carotid artery Paneth cell abdominal wall internal carotid artery epiblast ureter More reference expression data BioGPS More reference expression data
Gene ontology Molecular function single-stranded DNA binding nucleotide binding DNA helicase activity DNA binding protein binding hydrolase activity ATP binding helicase activity DNA replication origin binding Cellular component MCM complex membrane nucleus nucleoplasm Biological process G1 phase DNA replication cell cycle DNA replication initiation DNA unwinding involved in DNA replication G1/S transition of mitotic cell cycle double-strand break repair via break-induced replication pre-replicative complex assembly involved in nuclear cell cycle DNA replication DNA strand elongation involved in DNA replication mitotic DNA replication initiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4173 17217 Ensembl n/a ENSMUSG00000022673 UniProt P33991 P49717 RefSeq (mRNA) NM_005914 NM_182746 NM_008565 RefSeq (protein) NP_005905 NP_877423 NP_032591 Location (UCSC) n/a Chr 16: 15.44 – 15.46 Mb PubMed search [2] [3]
Wikidata
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Function

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported.^[5]

See also

• Mini Chromosome Maintenance

Interactions

MCM4 has been shown to interact with:

• Cell division cycle 7-related protein kinase,^[6]
• MCM2,^[6][7][8][9]
• MCM6,^{[6][7][8][10]}
• MCM7,^{[7][8][10][11]}
• ORC1L,^[6]
• ORC2L,^[6]
• ORC3L,^[6]
• ORC4L,^[6]
• ORC5L,^[6]
• ORC6L,^[6] and
• Replication protein A1.^[6]