RAP1A

Ras-related protein Rap-1A is a protein that in humans is encoded by the RAP1A gene.^[5]

RAP1A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1C1Y, 1GUA, 3KUC, 4KVG
Identifiers
Aliases	RAP1A, C21KG, G-22K, KREV-1, KREV1, RAP1, SMGP21, member of RAS oncogene family
External IDs	OMIM: 179520; MGI: 97852; HomoloGene: 2162; GeneCards: RAP1A; OMA:RAP1A - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p13.2 Start 111,542,218 bp[1] End 111,716,691 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 F2.2|3 46.45 cM Start 105,634,583 bp[2] End 105,708,652 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte tail of epididymis superficial temporal artery popliteal artery tibial arteries jejunal mucosa muscle layer of sigmoid colon gastric mucosa saphenous vein right ventricle Top expressed in tail of embryo genital tubercle jejunum granulocyte esophagus stomach thymus placenta dentate gyrus of hippocampal formation granule cell duodenum More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding protein-containing complex binding GTP binding protein binding GTPase activity GDP binding Cellular component cytosol endosome membrane myelin sheath plasma membrane guanyl-nucleotide exchange factor complex neuron projection extracellular exosome early endosome late endosome cytoplasm cell junction perinuclear region of cytoplasm specific granule membrane phagocytic vesicle glutamatergic synapse Biological process establishment of endothelial barrier positive regulation of glucose import microvillus assembly regulation of cell junction assembly regulation of insulin secretion small GTPase mediated signal transduction Rap protein signal transduction cellular response to organic cyclic compound nervous system development negative regulation of synaptic vesicle exocytosis liver regeneration protein transport response to antineoplastic agent response to carbohydrate negative regulation of collagen biosynthetic process cellular response to glucose stimulus signal transduction cellular response to nerve growth factor stimulus nerve growth factor signaling pathway positive regulation of ERK1 and ERK2 cascade positive regulation of protein kinase activity positive regulation of vasculogenesis positive regulation of GTPase activity cellular response to cAMP positive regulation of neuron projection development neutrophil degranulation positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis regulation of neurotransmitter receptor localization to postsynaptic specialization membrane protein localization to plasma membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5906 109905 Ensembl ENSG00000116473 ENSMUSG00000068798 UniProt P62834 P62835 RefSeq (mRNA) NM_001010935 NM_001291896 NM_002884 NM_001370216 NM_001370217 NM_001394066 NM_145541 RefSeq (protein) NP_001010935 NP_001278825 NP_002875 NP_001357145 NP_001357146 NP_663516 Location (UCSC) Chr 1: 111.54 – 111.72 Mb Chr 3: 105.63 – 105.71 Mb PubMed search [3] [4]
Wikidata
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Function

The product of this gene belongs to the family of Ras-related proteins. These proteins share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between RAP proteins and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. The product of this gene counteracts the mitogenic function of RAS because it can interact with RAS GAPs and RAF in a competitive manner. Two transcript variants encoding the same protein have been identified for this gene.^[6]

Interactions

RAP1A has been shown to interact with:

• C-Raf,^{[7][8][9][10]}
• MLLT4,^[11]
• PDE6D,^[12][13]
• RALGDS,^[11][14]
• RAPGEF2,^[15] and
• TSC2.^[16][17]