Liprin-alpha-1

Liprin-alpha-1 is a protein that in humans is encoded by the PPFIA1 gene.^[5][6][7]

PPFIA1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1N7F
Identifiers
Aliases	PPFIA1, LIP.1, LIP1, LIPRIN, PTPRF interacting protein alpha 1
External IDs	OMIM: 611054; MGI: 1924750; HomoloGene: 20802; GeneCards: PPFIA1; OMA:PPFIA1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.3 Start 70,270,690 bp[1] End 70,385,312 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F5 Start 144,030,495 bp[2] End 144,107,466 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve oocyte secondary oocyte buccal mucosa cell sperm Achilles tendon endothelial cell Epithelium of choroid plexus tibia visceral pleura Top expressed in zygote secondary oocyte genital tubercle tail of embryo primary oocyte ventricular zone superior cervical ganglion lip esophagus hair follicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding signal transducer activity Cellular component presynaptic active zone focal adhesion cytoplasm cytosol axon dendrite protein-containing complex Biological process cell-matrix adhesion negative regulation of stress fiber assembly signal transduction negative regulation of protein localization to plasma membrane neurotransmitter secretion glutamate secretion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8500 233977 Ensembl ENSG00000131626 ENSG00000288198 ENSMUSG00000037519 UniProt Q13136 n/a RefSeq (mRNA) NM_003626 NM_177423 NM_001378006 NM_001033319 NM_001195086 RefSeq (protein) NP_003617 NP_803172 NP_001364935 n/a Location (UCSC) Chr 11: 70.27 – 70.39 Mb Chr 7: 144.03 – 144.11 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a member of the LAR protein tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Alternatively spliced transcript variants encoding distinct isoforms have been described.^[7]

Interactions

Protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 has been shown to interact with:

• ERC2,^[8]
• GIT1,^[8][9]
• GRIP2,^[8][9]
• PPFIBP1,^[6]
• PPP2R5D,^[10]
• PTPRD,^[11]
• PTPRF,^[5][6][11] and
• PTPRS.^[6][11]