PTK2B

Protein-coding gene in humans From Wikipedia, the free encyclopedia

PTK2B

Protein tyrosine kinase 2 beta is an enzyme that in humans is encoded by the PTK2B gene.[5][6]

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PTK2B
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPTK2B, CADTK, CAKB, FADK2, FAK2, PKB, PTK, PYK2, RAFTK, protein tyrosine kinase 2 beta
External IDsOMIM: 601212; MGI: 104908; HomoloGene: 23001; GeneCards: PTK2B; OMA:PTK2B - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004103
NM_173174
NM_173175
NM_173176

NM_001162365
NM_001162366
NM_172498
NM_001360233

RefSeq (protein)

NP_004094
NP_775266
NP_775267
NP_775268

NP_001155837
NP_001155838
NP_766086
NP_001347162

Location (UCSC)Chr 8: 27.31 – 27.46 MbChr 14: 66.39 – 66.52 Mb
PubMed search[3][4]
Wikidata
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Function

Summarize
Perspective

This gene encodes a cytoplasmic protein tyrosine kinase that is involved in calcium-induced regulation of ion channels and activation of the MAP kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity.[7]

The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration [8] , nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation.[7] In addition, SOCE-induced Pyk2 activation mediates disassembly of endothelial adherens junctions, via tyrosine (Y1981-residue) phosphorylation of VE-PTP.[8]

This protein has been shown to bind a CRK-associated substrate, a nephrocystin, a GTPase regulator associated with FAK, and the SH2 domain of GRB2.[7]

The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene.[7]

Interactions

PTK2B has been shown to interact with:

See also

References

Further reading

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