RALGDS

Ral guanine nucleotide dissociation stimulator is a protein that is encoded by the RALGDS gene in humans.^[5][6]

RALGDS
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1RAX, 2B3A, 2RGF, 3KH0
Identifiers
Aliases	RALGDS, RGDS, RGF, RalGEF, ral guanine nucleotide dissociation stimulator
External IDs	OMIM: 601619; MGI: 107485; HomoloGene: 4562; GeneCards: RALGDS; OMA:RALGDS - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q34.13-q34.2 Start 133,097,720 bp[1] End 133,149,334 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 A3 Start 28,403,137 bp[2] End 28,443,093 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum pituitary gland anterior pituitary C1 segment skin of abdomen skin of leg substantia nigra granulocyte amygdala caudate nucleus Top expressed in lactiferous gland entorhinal cortex perirhinal cortex CA3 field genital tubercle spermatid primary visual cortex superior frontal gyrus lip ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding guanyl-nucleotide exchange factor activity GTPase regulator activity Cellular component cytosol brush border cytoplasm nucleus Biological process small GTPase mediated signal transduction Ras protein signal transduction signal transduction regulation of catalytic activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5900 19730 Ensembl ENSG00000160271 ENSMUSG00000026821 UniProt Q12967 Q03385 RefSeq (mRNA) NM_006266 NM_001042368 NM_001271774 NM_001271775 NM_001271776 NM_001145834 NM_001145835 NM_001145836 NM_009058 RefSeq (protein) NP_001035827 NP_001258703 NP_001258704 NP_001258705 NP_006257 NP_001139306 NP_001139307 NP_001139308 NP_033084 Location (UCSC) Chr 9: 133.1 – 133.15 Mb Chr 2: 28.4 – 28.44 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

RALGDS has been shown to interact with:

• Arrestin beta 1,^[7]
• Arrestin beta 2,^[7]
• HRAS,^{[5][8][9][10][11][12][13][14]}
• KRAS,^[8][10]
• MRAS,^[15][16]
• RAP1A,^[9][17]
• RAP2A,^[17]
• RAPGEF2,^[8] and
• RRAS.^[8]