Rap GTP-binding protein

Rap GTP-binding protein also known as Ras-related proteins or simply RAP is a type of small GTPase, similar in structure to Ras.

RAP1A, member of RAS oncogene family
Identifiers
Symbol	RAP1A
NCBI gene	5906
HGNC	9855
OMIM	179520
RefSeq	NM_002884
UniProt	P62834
Other data
Locus	Chr. 1 p13.3
Search for Structures Swiss-model Domains InterPro

RAP1B, member of RAS oncogene family
Identifiers
Symbol	RAP1B
NCBI gene	5908
HGNC	9857
OMIM	179530
RefSeq	NM_015646
UniProt	P61224
Other data
Locus	Chr. 12 q14
Search for Structures Swiss-model Domains InterPro

These proteins share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between RAP proteins and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. RAP counteracts the mitogenic function of RAS because it can interact with RAS GAPs and RAF in a competitive manner.^[1][2]

Family members

Human genes that encode Ras-related proteins include:

• RAP1A, RAP1B
• RAP2A, RAP2B, RAP2C
• RAB5C