RFC2

Replication factor C subunit 2 is a protein that in humans is encoded by the RFC2 gene.^[5][6][7]

RFC2
Identifiers
Aliases	RFC2, RFC40, replication factor C subunit 2
External IDs	OMIM: 600404; MGI: 1341868; HomoloGene: 6885; GeneCards: RFC2; OMA:RFC2 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q11.23 Start 74,231,499 bp[1] End 74,254,458 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 G2|5 74.68 cM Start 134,610,220 bp[2] End 134,630,659 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence gonad monocyte granulocyte muscle of thigh testicle skin of leg mucosa of transverse colon skin of abdomen Top expressed in spermatid spermatocyte ventricular zone seminiferous tubule granulocyte fetal liver hematopoietic progenitor cell embryo epiblast abdominal wall embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding DNA binding single-stranded DNA helicase activity protein binding enzyme binding ATP binding DNA clamp loader activity Cellular component DNA replication factor C complex Ctf18 RFC-like complex nucleoplasm nucleus Biological process nucleotide-excision repair, DNA gap filling error-free translesion synthesis error-prone translesion synthesis DNA replication positive regulation of DNA-directed DNA polymerase activity translesion synthesis transcription-coupled nucleotide-excision repair nucleotide-excision repair, DNA incision nucleotide-excision repair, DNA incision, 5'-to lesion DNA repair telomere maintenance via semi-conservative replication DNA-dependent DNA replication regulation of signal transduction by p53 class mediator Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5982 19718 Ensembl ENSG00000049541 ENSMUSG00000023104 UniProt P35250 Q75MT5 Q9WUK4 RefSeq (mRNA) NM_001278791 NM_001278792 NM_001278793 NM_002914 NM_181471 NM_020022 RefSeq (protein) NP_001265720 NP_001265721 NP_001265722 NP_002905 NP_852136 NP_002905.2 NP_064406 Location (UCSC) Chr 7: 74.23 – 74.25 Mb Chr 5: 134.61 – 134.63 Mb PubMed search [3] [4]
Wikidata
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Function

The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins, proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also called activator 1, is a protein complex consisting of five distinct subunits of 145, 40, 38, 37, and 36.5 kD. This gene encodes the 40 kD subunit, which has been shown to be responsible for binding ATP. Deletion of this gene has been associated with Williams syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been described.^[7]

Interactions

RFC2 has been shown to interact with BRD4,^[8] CHTF18,^[9][10] PCNA,^[11][12][13] RFC4^[11][14] and RFC5.^[11][14]